Beecham Pharmaceutical

Fig. 23.2 Isolators used for sterility testing. The operator works within the hood which is suspended inside the cubicle the hydrogen peroxide generator which is used to sterilize the isolators is shown in the left foreground. (Courtesy of SmithKline Beecham Pharmaceuticals.)...

Xiayang Qiu SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, U.S.A. 

Synthetic Chemistry Department, SmithKIine Beecham Pharmaceuticals, P.O. Box 1539, King of Prussia, PA 19406. 

The synthesis of eprosartan mesylate (6) by SmithKline Beecham Pharmaceuticals is described in Scheme 9.9. The synthesis of the precursors 43 and 45 were required for imidazole formation. Thus, valeronitrile (40) was converted to the imidate salt 41 with... 

Rhodium-catalyzed diazo insertions, known since 1976, have been extensively reviewed39. The first report40 indicated that rhodium acetate efficiently catalyzes diazo insertion into an alkene, giving the cyclopropane. Rhodium-catalyzed intramolecular C-H insertion was first observed by workers at Beecham Pharmaceuticals, who reported that 1, on exposure to a catalytic amount of rhodium acetate, cyclizes cleanly to the /1-lactam41. This approach to thienamycin derivatives has been developed further by these workers42,43. 

Brand Name/ Company Ancet (cefazolin)/SmithKline Beecham Pharmaceuticals Cefotan (cefotetan)/Zeneca Pharmaceuticals Rocephin (ceftriaxone)/Roche Pharmaceuticals Maxipime (cefepime)/Bristol-Myers Squibb Company... 

SmithKIine Beecham Pharmaceuticals, Synthetic Chemistry Department Old Powder Mills, Tonbridge TN11 9AN, U.K. 

Rodert Southgate Neal F. Osborne SmithKline Beecham Pharmaceuticals (U.K.) Additional Reading... 

Neal F. Osborne, SmiihKIine Beecham Pharmaceuticals. Surrey. United Kingdom, http //www.sb.com/, Antibiotics 0-Lactams Lloyd Osipow, New York. NY. Surface Chemistry Michael J. Owen, Dow Coming Corporation. Midhmd, Ml. http //www. dowcoming.com/, Release Agents... 

SmithKline Beecham Pharmaceuticals in Harlow, UK, carried out Wittig reactions using a microchip reador under eledroosmotic flow conditions. 2-Nitrobenzyltri-phenylphosphonium bromide was readed with methyl 4-formylbenzoate and four other aldehydes, 3-benzyloxybenzaldehyde, 2-naphthaldehyde, 5-nitrothiophene-2-carboxaldehyde and 3-dimethylamino-4-propoxybenzaldehyde [16,17]. 

Trifluoperazine Smitkline Beecham Pharmaceuticals (India) Ltd. India [64]... 

DEREK R. BUCKLE and IVAN L PINTO SmithKIine Beecham Pharmaceuticals, Epsom, UK... 

SmithKline Beecham Pharmaceuticals, Biosciences Research Centre, Great Bur ... 

Roger Dean is a Fellow of Royal Institute of Chemistry, an Associate of Institute of Managers, and a Graduate of Royal Institute of Chemistry by examination. Mr. Dean has spent 14 years in Quality Control/Analytical Chemistry and 2 years in Production Chemistry at Beecham Pharmaceuticals, and 11 years in Quality Operations/Analytical Chemistry and 9 years in IT support and projects at Pfizer Limited (Pharmaceuticals). Mr. Dean has also been involved in project managing the implementation of an EDMS system with significant involvement in its design and validation and also in several other vahdation projects. 

Pfizer Central Research SmithKline Beecham Pharmaceuticals Strem Chemicals UK... 

Department of Fermentation and Natural Product Sciences, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park North, Third Avenue, Harlow, Essex, CM 19 SAW, U.K. 

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