Workers clinical

M. N. Gleason and co-workers. Clinical Toxicology of Commercial Products, Williams Wilkins, Co., Baltimore, Md., 1969. 

R. E. Gosselin and co-workers. Clinical Toxicology of Commercial Products, Williams Wilkins Co., Baltimore, Md., 1976, p. 86 M. Sittig, Hazardous and Toxic Effects of Industrial Chemicals, Noyes Data Corp., Park Ridge, N.J., 1979, p. 102. 

FWC, Farm Workers Clinics and Sacramento Blood Bank, 1975 SBB, Sacramento Blood Bank, 1976 NW, no field work past 30 days and W, worked in fields past 30 days. 

Ribak J, Lilis R, Suzuki Y, et al. 1988. Malignant mesothelioma in a cohort of asbestos insulation workers Clinical presentation, diagnosis, and causes of death. Br J Ind Med 45 182-187. 

PARK, H.S. HONG, C-S. (1991) The significance of specific IgG and IgG4 antibodies to a reactive dye in exposed workers, Clinical and Experimental Allergy. 21, 357-362. 

WASS, U BELIN, L. ERIKSSON, N.E. (1989) Immunological specificity of chloramine-T-induced IgE antibodies in serum from a sensitized worker. Clinical Allergy, 19, 463-471. 

ZAMMIT-TABONA, M SHERKIN, M KUEK, K CHAN, H. CHAN-YEUNG, M. (1983) Asthma caused by diphenylmethane diisocyanate in foundry workers. Clinical, bronchial provocation and immunologic studies. American Review of Respiratory Disease, 128, 226-230. 

Anemia Smelter workers and a chemicals plant (n = 160) BLLs about >50 pg/dL Anemia (Hgb <14 g/dL) seen in 21% of workers. Clinically important outcome. Baker et al. 1979... 

For radiation doses <0.5 Sv, there is no clinically observable iacrease ia the number of cancers above those that occur naturally (57). There are two risk hypotheses the linear and the nonlinear. The former implies that as the radiation dose decreases, the risk of cancer goes down at roughly the same rate. The latter suggests that risk of cancer actually falls much faster as radiation exposure declines. Because risk of cancer and other health effects is quite low at low radiation doses, the iacidence of cancer cannot clearly be ascribed to occupational radiation exposure. Thus, the regulations have adopted the more conservative or restrictive approach, ie, the linear hypothesis. Whereas nuclear iadustry workers are allowed to receive up to 0.05 Sv/yr, the ALARA practices result ia much lower actual radiatioa exposure. 

Epidemiological and clinical studies of workers and other long-term case-control studies... 

It has been shown by various workers 3 that the action of alkaloids on protozoa is influenced in a marked degree by the pH of the medium in which the action is exerted, and at a pH of 6-2 to 6-3 aK-tetra-n-amyl-diamino-n-decane proved to be 3 to 5 times as active as emetine, and even in presence of blood at least as active. In view of these promising results of in vitro tests the synthetic product was tried clinically, but proved not to be sufficiently active to be of practical value. This work is being continued and extended by a team of workers led by Goodwin and Sharp, who have published two papers dealing (1) with amines which can be regarded, like Pyman s type A, as diamines derivable from the accepted emetine formula and (2) variants on the bis(diamylamino) decane referred to above. 

Krogsgaard-Larsen and co-workers have protected the P-keto functionality as a ketal as a modification to the traditional conditions so attack of hydroxylamine is directed towards the ester. They prepared hydroxamic acid 10 from ester 9 then cyclized with sulfuric acid to isoxazole 11, in route to 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP), a selective GABAa receptor agonist studied clinically for insomnia. 

In a study of 135 workers in the ehemical industry who handle methyl parathion, the methyl parathion concentration in plasma, the 4-nitrophenol concentration in urine, and the cholinesterase and acetylcholinesterase activities were determined to assess the pesticide burden in such workers (Leng and Lewalter 1999). The mean concentration of methyl parathion in the plasma of the workers was 233 pg/L no clinical symptoms were reported by the workers. In an additional group of 19 workers handling methyl parathion, who were also exposed to the pyrethroid cyfluthrin, the mean concentrations of methyl parathion in plasma were 269 and 241 pg/L (for groups without and with clinical S5miptoms, respectively), and 7 of the workers exhibited skin paraesthesia, while none of the 427 workers exposed only to the pyrethroid experienced the symptom (Leng and Lewalter 1999). 

Midtling JE, Barnett PG, Coye MJ, et al. 1985. Clinical management of field worker organophosphate poisoning. West Med 142 514-518. 

---