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Wnt Signaling

Lustig B, Behrens J (2003) The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 129 199-221... [Pg.309]

Wnt Wnts are secreted signalling molecules best characterized for their roles in development. The Wnt signalling pathway is also implicated in cancer... [Pg.1216]

SB-505124, both of which target the TbRI kinase domain, are in preclinical use. An alternative approach to inhibiting TGF- 3 signaling is to focus on the tumor suppressive function of this pathway. Promising future treatments will focus on pathways that are activated when the TGF-P signaling tumor suppressor pathway is inactivated. Examples are inhibitors to wnt signaling, CDK4 activation and IL-6. [Pg.1233]

Low-Density Lipoprotein Receptor Gene Family Wnt Signaling... [Pg.1316]

Similarly, in developing Drosophila the response to wg is influenced by the relative abundance and ligand affinity of receptors expressed in the target tissue. A synthesis of the available data from all species suggests that the response to a specific Wnt signal in vivo is influenced both by the particular Wnt protein secreted and by the receptors and other downstream molecules present in the target tissue. [Pg.1317]

Adenomatosis Polyposis Coli (APC). Whereas Dvl is a Wnt pathway activator, GSK3, Axin and APC are all inhibitors. Axin and APC help to stabilize the activity of GSK3, keeping (3-catenin levels low and Wnt target gene transcription off in the absence of a Wnt signal (Fig. 2a). [Pg.1317]

Wnt Signaling. Table 1 Some of the major Wnt signaling components9 in human cancer... [Pg.1320]

Wnt Signaling (general) Wnt4 Sfrp Fz LRP5 Dvl GSK3 p-catenin... [Pg.1321]

Polycystic kidney disease (Polycyst in-1 activates canonical Wnt signaling pathway) Injury-induced renal fibrosis Heart failure Ulcerative colitis Osteoporosis-Pseudoglioma Syndrome (genetic syndrome of defective bone formation) Ulcerative colitis Familial Alzheimer s disease (through interaction with Presenilin-1) Familial Alzheimer s disease (through interaction with Presenilin-1)... [Pg.1321]

Veeman MT, Axelrod ID, Moon RT (2003) A second canon functions and mechanisms of p-catenin-independent Wnt Signaling. Dev Cell 5 367-377... [Pg.1322]

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See also in sourсe #XX -- [ Pg.55 ]



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