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Wingless/Wnt signaling

VI. Tcf/p-Catenin Complexes Bipartite Transcription Factors Involved in Wingless/Wnt Signaling... [Pg.1]

VI. Tcf/p-CATENIN COMPLEXES BIPARTITE TRANSCRIPTION FACTORS INVOLVED IN WINGLESS/Wnt SIGNALING... [Pg.8]

Fig. 2 An alignment of the Wingless/Wnt signaling components. Interactions resulting in stimulation (arrows) or inhibition (bars) of activity are shown. The relationship between APC-mediated (3-catenin/Armadillo regulation and Wingless/Wnt signaling is still somewhat controversial. Fig. 2 An alignment of the Wingless/Wnt signaling components. Interactions resulting in stimulation (arrows) or inhibition (bars) of activity are shown. The relationship between APC-mediated (3-catenin/Armadillo regulation and Wingless/Wnt signaling is still somewhat controversial.
Transcriptional activation of target genes in response to Wingless/Wnt signaling is dependent on the nuclear translocation of free cytoplasmic p-... [Pg.10]

These recqrtors are integral components of the wingless (Wilt) signaling cascade by acting as coreceptors to frizzled. Simultaneous binding of Wnt ligands to... [Pg.707]

The Wingless-Wnt pathway and p-catenin-APC signalling have much in common. For example, when the Wingless-Wnt pathway is activated in colon cells, the serine/... [Pg.289]

The Wnt/wingless family of signaling molecules are involved in diverse ontogenic processes. In the canonical pathway, the Wnt signal is transduced... [Pg.91]

Both Hedgehog and Wingless/Wnt contain lipid anchors that can tether them to cell membranes, thereby reducing their signaling range. [Pg.644]

Wingless and other Wnt signals act through two cell-surface proteins, the receptor Frizzled and coreceptor Lrp, and an intracellular complex containing p-catenin (see Figure 15-32). Wnt signaling promotes the stability and nuclear localization of p-catenin, which either directly or indirectly promotes activation of the TCF transcription factor. [Pg.644]

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Wnt Signaling

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