What It Takes

The authors are grateful for the contributions/suggestions made by Professors Clark Liu (University of Hawaii), Eugene Tseng (University of California, Los Angeles), and Yue-hwa Yu (National Taiwan University) to part of the content of this chapter. 

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Traditionally, in pursuit of their structure-activity relationships, medicinal chemists had focused almost exclusively on finding compounds with greater and greater potency. However, these SARs often ended up with compounds that were unsuitable for development as pharmaceutical products. These compounds would be too insoluble in water, or were not orally bioavailable, or were eliminated too quickly or too slowly from mammalian bodies. Pharmacologists and pharmaceutical development scientists for years had tried to preach the need for medicinal chemists to also think about other factors that determined whether a compound could be a medicine. Table 1.1 lists a number of factors that determine whether a potent compound has what it takes to become a drug. Experimentally, it was difficult to quantitate these other factors. Often, the necessary manpower resources would not be allocated to a compound until it had already been selected for project team status. 

TABLE 1.1 What It Takes for a Compound (Ligand) to Become a... 

During the cleanse, it is best to avoid stimulants such as coffee, tea or sedatives such as alcohol. Avoid smoking. A calm emotional body is also best during this time. Do what it takes to be relaxed and avoid violent TV or novels. Spend time resting, contemplating nature or soaking in warm water scented with essential oils. Enjoy the process of purifying your body and mind. 

The main business of most chemical companies is to manufacture products by means of controlled chemical reactions. The reactivity that makes chemicals useful can also make them hazardous. Chemical reactions are usually carried out without mishap, but sometimes they get out of control because of problems such as the wrong or contaminated raw material being used, changed operating conditions, unanticipated time delays, failed equipment, incompatible materials of construction, or loss of temperature control. Such mishaps can be worse if the chemistiy under both normal and abnormal conditions is not fully understood. Therefore, it is essential that chemical process designers and operators understand the nature of the reactive materials andchemistry involved and what it takes to control intended reactions and avoid unintended reactions throughout the entire life cycle of a process facility. 

Step 2 involves knowing what properties turn a macromolecule into a receptor. All receptors may be macromolecules, but all macromolecules are certainly not receptors. Receptor macromolecules are frequently proteins or glycoproteins. Certain properties must be present if a macromolecule is going to have what it takes to be a druggable target. The receptor macromolecule must be intimately connected with the disease in question, but not integral to the normal biochemistry of a wide range of processes. 

Behind every heroic moment, of course, are countless hours of preparation. Career firefighters are highly trained professionals. Their services are essential to every community and every stretch of land across this country. If you make this your career choice, rest assured that the need for firefighters is constant and the job prospects are promising. But this is a competitive field. Wherever you apply, you will need to show that you have what it takes to meet the demands of the job—and succeed in every stage of the hiring process. 

The written exam is your first opportunity to show that you have what it takes to be a firefighter. As such, it is extremely important. Candidates who don t pass the written exam don t go any farther in the selection process. Furthermore, the written exam score often figures into applicants rank on the eligibility list in some cases, this score by itself determines your rank, whereas in others it is combined with other scores, such as physical ability or oral board scores. In those places, a person who merely passes the written exam with a score of, say, 70, is unlikely to be hired when there are plenty of applicants with scores in the 90s. The exam bulletin may specify what your rank will be based on. 

The practice exam that follows is another type of test often used to see if firefighter candidates have what it takes to do the job. A test like this mostly tries to assess whether you have what it takes to learn the job it tests some of the basic skills you need to be able to do well in your firefighter training program. This practice exam includes five areas reading comprehension, verbal expression, logical reasoning, mathematics, and mechanical aptitude. 

In questions based on floor plans, your ability to observe and judge location and potential hazards is being challenged to see if you have what it takes to become a firefighter. The floor plan or fire scene may... 

Leading is a concept that is hedged about with a considerable amount of mystique. Leadership qualities are often thought of as something you either have or do not have. There have been attempts to look at leadership in other ways, for example as a function of the task or situation, but these approaches can still leave managers bemused as to whether they have what it takes to lead in their particular circumstances. The purpose of this chapter is to show how leading can be a feasible activity for any manager. 

Of course, values statements may be useful to try to change yourself, and you may write a value that you would like to emphasize in the future. Such items on your values list have a place, but be sure you are truly committed to doing what it takes to alter your behavior and embrace the value. Simply mouthing the value, placing it on your values statement, and pretending it is yours is not enough. 

Figures 8-9 illustrate what it takes to complete the project structure of an international pipeline in a relatively simple case, where the upstream part of the project is on PSA terms and there are only two countries involved. The case is that of Unocal s proposed pipeline from Bangladesh to India. Under the adopted approach, a gas export pipeline agreement and a gas transportation agreement would have to be negotiated, and title on gas would pass to customers at the border. This structure allows national regimes to apply for the sections of the pipeline on the territory of each of the two countries, but leads to a necessity to involve a host of parties and negotiate multiple agreements of several types (cf. Figure 8).

What have your past experiences with teachers shown you about what it takes to be a good teacher ... 

The best way I can think to explain why it s worth spending more on organic produce is to introduce my CSA farmer. Which is funny because I spend a lot less on my CSA than I do buying organic produce during the winter. But I want to give you a sense of what it takes to be an organic farmer. 

Lombardi V Jr. 2001. What It Takes to Be 1 Vincent Lombardi on Leadership, p. 2. New York McGraw-Hill. 

Not to be deterred, Chemist A s legal counsel convinces his client that he should not concede yet. Chemist A s counsel informs his client that he has carefully reread the text of the 102(g) statute and he has cleverly discovered in the fine print that it gives priority to the earlier inventor, but only in cases in which that inventor has not abandoned, suppressed or concealed the invention. Chemist A s side needs only to establish that Chemist B committed one or more of these three sins. Since 102(g) is concerned with priority contests between parties, the guilty party will be put behind the other party and lose the priority contest together with any patent to the contested invention. This begs the question of what it takes for an invention to be abandoned suppressed, or concealed, and, not surprisingly, this is a question of the particular... 

Although hard work is often essential, I disagree with Einstein that it s 99% of what it takes to be a genius plenty of people become successful without working hard. 

One thing these numbers don t tell you is what it takes to get a 5 or a 4. The number of points to achieve these grades will differ slightly from year to year, but they remain relatively consistent over time. The Chemistry test is intentionally made so that a score of 100 percent is extremely unlikely. In most administrations, scores of 50—60 percent usually receive scores of 5. 

It is from these good men that I learned what it takes to devote one s life to an idea, even if all seems to be destined to another generation of students. Which is what really matters, in the end, because a new idea is all the more beautiful the greater is its power to convince one that it really belongs to the future. 

BEDT-TTF (17a), affectionately known as "ET." An understanding of what it takes to make organic metals evolved gradually [23-26]. 

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