Wear debris immune responses

In Vitro and In Vivo Models Used to Study the Immune Response to UHMWPE Wear Debris... [Pg.341]

Exacerbation of the Immune Response to Wear Debris as a Result of Subclinical Infection Comparative Pathophysiologic Changes in Periprosthetic Hip Tissues from Historical and Highly Crosslinked UHMWPE Implant Retrievals Conclusion Acknowledgments References... [Pg.341]

Since the seminal work by Hans-Georg Willert, which demonstrated macrophage activation by UHMWPE wear debris, interest in understanding the complete immune response in periprosthetic tissue has exploded [4]. For most nonimmunologists, this complex area is difficult to grasp, but hopefully the following information will provide a basis for a better understanding of the immune system. [Pg.342]

The involvement of NK cells in the removal of damaged cells or cells that have lost self recognizing surface receptors in periprosthetic tissues has not been investigated. Like the Th17 cells, NK cells secrete cytokines that regulate T and B cell responses, and they are involved in the development of autoimmune diseases. Finally, the disregu-lation of Treg cells may also affect the tissue response to wear debris by failure to suppress the activity of stimulated immune cells. The involvement of T cell subsets and NK cells in periprosthetic tissue inflammation associated with UHMWPE wear debris will require additional studies. [Pg.345]

IN VITRO AND IN VIVO MODELS USED TO STUDY THE IMMUNE RESPONSE TO UHMWPE WEAR DEBRIS... [Pg.346]

EXACERBATION OF THE IMMUNE RESPONSE TO WEAR DEBRIS AS A RESULT OF SUBCLINICAL INFECTION... [Pg.349]

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