Pathophysiologic changes

Of the thousands of different enzymes present in the human body, those that fulfill functions indispensable to cell vitality are present throughout the body tissues. Other enzymes or isozymes are expressed only in specific cell types, during certain periods of development, or in response to specific physiologic or pathophysiologic changes. Analysis of the presence and distribution of enzymes and isozymes— whose expression is normally tissue-, time-, or circumstance-specific—often aids diagnosis. 

Explain the pathophysiologic changes associated with menopause. 

The pathophysiologic changes that occur during the perimenopausal and menopausal periods are caused by the decrease and eventual loss of ovarian follicular activity. As women age, the number of ovarian follicles decreases, and the remaining follicles require higher levels of FSH for maturation and ovulation. During perimenopause, FSH concentrations... 

Once through the blood-brain barrier, pathogens thrive and replicate due to limited host defenses in the CNS. Figure 67-1 depicts the pathophysiologic changes associated... 

Pathophysiologic changes associated with menopause are caused by loss of ovarian follicular activity. The postmenopausal ovary is no longer the primary site of estradiol or progesterone synthesis. 

Tewe 00, Maner JH. 198 lb. Performance and pathophysiological changes in pregnant pigs fed cassava diets containing different levels of cyanide. Res Vet Sci 30 147-151. 

Van Dijk, W., Havenaar, E.C. and Brinkman-Van der Linden, E.C. (1995) ai-acid glycoprotein (orosomucoid) pathophysiological changes in glycosylation in relation to its function. 

Substance abusers can exhibit pathophysiologic changes related to substance abuse. Pathophysiological changes are debilitating changes, including ... 

Early increases in TNFa, IL-6, and IL-ip levels following transient cerebral ischemia suggest that regionally selective increases in cytokines may be involved in the pathophysiological changes in the hippocampus and striatum following transient cerebral ischemia. ... 

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