Warfarin potassium

The coumarin anticoagulants include dicumarol, warfarin sodium (coumadin sodium), warfarin potassium (Athrombin-K), acenocoumarol (Sintrom), and phenprocoumon (Liquamar). The inanedione derivatives are phenindione (Hedulin), diphenadione (Dipaxin), and anisindi-... 

Warfarin, 1064 Warfarin potassium, 1064 Warfarin sodium, 1064 Warfilone, 1064 Wamerin, 1064 Wasangor, 920... 

Warfarin Potassium, USP. Warfarin potassium. 3-(o acetonylbenzyl)-4-hydroxycoumarin potassium salt (Athrombin-K). is readily abs orbed after oral administration. 

The coumarin anticoagulants include dicumarol, warfarin sodium (coumadin sodium), warfarin potassium (Athrom-bin-K), acenocoumarol (Sintrom), and phenprocoumon (Liquamar). The inanedione derivatives are phenindione (Hedulin), diphenadione (Dipaxin), and anisindione (Miradon). The pharmacological properties of oral anticoagulants are identical qualitatively, but their pharmacokinetic parameters and their toxicities vary. Racemic warfarin sodium is the most widely used anticoagulant. Antithrombotic drugs are used clinically either to prevent the formation of blood clots within the circulation (anticoagulant) or to dissolve a clot that has already formed (thrombolytic). 

The coumarin anticoagulants include dicumarol, warfarin sodium (coumadin sodium), warfarin potassium (Athrombin-K), acenocoumarol, and phenprocouman. Phenprocouman, acenocoumarol, and ethyl biscoumacetate are not generally available in the United States but are prescribed in Europe and elsewhere. Phenprocouman (Marcumar) has a longer plasma half-life (5 days) than warfarin, as well as a somewhat slower onset of action and a longer duration of action (7 to 14 days). It is administered in daily maintenance doses of 0.75 to 6.0 mg. By contrast, acenocoumarol (Nicoumar-lone Sinthrome) has a shorter half-life (10 to 24 hours), a more rapid effect on the prothrombin time, and a shorter duration of action (2 days). The maintenance dose is 1 to 8 mg daily. Ethyl biscoumacetate (Tromexane) has a very short half-life of 2 to 3 hours and is seldom used. 

CAS Registry No. 81-81-2 (warfarin), 129-06-6 (warfarin sodium), 2610-86-8 (warfarin potassium)... 

Takase K, Fujioka H, Ogasawara M, Aonuma H, Tameda Y, Nakano T, Kosaka Y. Drug-induced hepatitis during combination erapy of warfarin potassium and ticlopidine hydrochloride, Mie MedJ 990) 40, 27-32. 

Nemoto C, Ikegami Y, Shimada J, Tsukada Y, Abe Y, Tase C. Acute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin a case report. J Anesth 2012 26(6) 943-4. 

Aminophylline Aminophylline should not be mixed with acidic drugs, as it becomes precipitated if the pH of the final solution falls below pH 8. Mixture with glucose may increase the pH above 10 where proteins, such as insulin and erythromycin, are unstable. Some drugs that are incompatible with aminophylline include amiodarone, benzylpenicillin potassium, cisatracurium, ceftazidime, ceftriaxone, dobutamine, tetracycline hydrochloride, verapamil hydrochloride, warfarin sodium, and vitamin B and C injection. Alcohol-free theophylline should be stored in amber-colored containers maximum care must be taken to protect it against exposure to light.92-94... 

Another patient taking digoxin, potassium chloride, docusate, diazepam and warfarin 2.5 mg daily, was also given aminosalicylic acid 12 g, isoniazid 300 mg and pyridoxine 100 mg daily, and at the same time the warfarin dose was doubled to 5 mg daily. His prothrombin time increased from 18 to 130 seconds over 20 days but no signs of haemorrhage were... 

In eontrast, another report deseribes a patient who, following a myoear-dial infaretion, was given warfarin 3 mg daily and disopyramide 100 mg every 6 hours with digoxin, furosemide and potassium supplements. When the disopyramide was withdrawn his warfarin requirements doubled over a 9-day period. ... 

The loop diuretics, bumetanide, furosemide and torasemide, the potassium-sparing diuretic spironolactone, and the thiazides chlortalidone and chlorothiazide, have all been shown either not to interact or to cause only a small reduction in the effects of the coumarin anticoagulants of minimal or no clinical importance. The lack of reports of clinically relevant interactions su ests that, in general, diuretics do not interact with anticoagulants. The possible exception is etacrynic acid, which on rare occasions has caused a marked increase in the effects of warfarin. 

However, a patient stabilised on warfarin, ferrous sulfate, phenobarbital and sulfasalazine had a marked increase in his prothrombin time ratio from about 3.2 to 10 after taking sulindac 100 mg twice daily for 5 days. There are 4 similar cases of this interaction on record. One of the patients had a gastrointestinal bleed after taking only three 100-mg doses of sulindac, although this patient was also taking flurbiprofen. Another patient was stabilised on about a 40% lower dose of warfarin with continuation of the sulindac. Another patient had a potassium-losing renal tubular defect, which was thought to contribute to the interaction. ... 

Loftin JP, Vesell ES. Interaction between sulindac and warfarin different results in normal subj ects and in an unusual patient with a potassium -losing renal tubular defect J Clin Pharmacol (1979) 19,733 2. 

Use of diuretics is generally cautioned in persons taking drugs with narrow therapeutic ranges (small differences between the effective and toxic doses), such as warfarin, steroids (i.e., prednisone), digoxin, tacrolimus, cyclosporine, valproic acid, phenytoin, and carbemaze-pine, as shifts in serum levels of sodium and potassium may affect serum levels of these drugs. Serum electrolyte shifts, notably sodium, can also cause an increase in serum... 

Potassium aluminum sulfate Potassium aspartate Potassium bromate Potassium chlorate Potassium iodate Potassium perchlorate Potassium periodate Potassium sulfate, anhydrous Potassium warfarin Potato starch Pregnenolone acetate Preludin Probarbital... 

Figure 8 A reaction progress curve obtained when 20 pM warfarin was mixed with 1 pM HSA. in this reaction, 1 pM aibumin was reacted with 10 pM warfarin (finai concentrations) in 100 mM potassium phosphate buffer at pH 7.4 also containing 0.8% NaCI, at 25 C. The fluorescence of the warfarin was excited at 330 nm, and the emission intensi at 360 nm and above was selected by a cut-off filter. The inset shows a plot of the pseudofirst-order rates, k, for the reactions between various concentrations of warfarin and 1 pM HSA against the final concentration of warfarin used. We are indebted to Miss Sue Twine for the provision and use of these data.

Outcomes following unintentional and supratherapeutic ingestions of a patient s own BB or CCB have been reviewed [37 ]. Out of 436 cases reviewed, symptoms developed in 44 (10.1%) and 32 (7.3%) cases were admitted due to the ingestion. Of those admitted, five (15.6%) received treatment (three intravenous fluids, one glucagon and one calcium). Only one death was recorded in a 90-year-old lady who ingested four doses of her daily medications diltiazem 240 mg, atenolol 50 mg, glyburide 5 mg, warfarin 2 mg, frusemide 40 mg, lisinopril 5 mg, potassium chloride 20 mg, Zaroxyln 5 mg and hydralazine 25 mg. She was reported to have died of shock after the family initiated a do-not-resuscitate directive. 

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