Walker carcinoma

In a similar study by Yang and Huang (1996), melanoma tumors in mice were in vivo transfected by the direct intratumoral administration of naked pDNA, resulting in reporter gene expression for up to ten days. In another study, Walker 256 carcinoma tumors in rats were found to express CAT after intratumoral injection of naked pDNA encoding CAT (Nomura et al., 1997). More recently electroporation has been used to deliver naked pDNA to tumors (described further in the following section). 

Heparin causes a reduction in mitotic index and a decrease in tumour volume for Ehrlich ascites tumours in mice . Polyethylene sulphonates having molecular weights between 15,000 and 35,000, also have antineo-plastic activity in mice against ascites tumours, carcinomas and leukaemias . Heparin has been found to reduce markedly the number of pulmonary metastases in rats receiving intravenous Walker 256 carcinoma cells . Evans blue in the presence of a sulphated pectin entered tumour cells but not normal tissue cells s. The anti-immunochemical action of heparin has been used successfully for tumour heterografts Ass. 

Both these compounds have shown aetivity in miee, dog and rats against Walker 256 carcinomas. 

Hexahydropyrimidines have also been used as carriers for the nitrogen mustard function. Compounds of type (CIV), prepared by the condensation of substituted 1,3-diaminopropanes with substituted benzaldehydes containing a p-bis( -chloroethyl)amine moiety, exhibit tumour-inhibitory activity against Walker 256 carcinoma in rats [543,544]. The degree of activity of these compounds is believed to be dependent on the electron-donating ability of the substituents on the aryl moiety [543]. 

Platinum Complexes - cls-Diamminedichloroplatlnum (25), exhibited potent antitumor activity against sarcoma 180, Ehrlich ascites carcinoma, leukemia L-1210, Dunning ascites leukemia, Walker 256 carcinoma, DMBA-Induced mammary carcinoma, and virus-induced reticulum cell sarcoma in experimental animals.179,180... 

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