Von Hippel-Lindau tumor suppressor

Staller P, Sulitkova J, Lisztwan J, et al. Chemokine receptor CXCR4 down-regulated by von Hippel-Lindau tumor suppressor pVHL. Nature 2003 425 307-311. 

Pause, A., et al.. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci USA, 1997, 94(6), 2156-61. 

Loneegan, K. M. et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. 

Ivan, M. and Kaelin, W. G., Jr. The von Hippel-Lindau tumor suppressor protein. Curr Opin Genet Dev 2001, 3 3, 27-34. 

Ubiquitination of a novel deubiq-uitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein, J Biol Chem,... 

Kim W, Kaelin WG Jr. The von Hippel-Lindau tumor suppressor protein new insights into oxygen sensing and cancer. Curr. Opin. Genet. Dev. 2003 13 55-60. 

Sufan RI, Jewett MAS, Ohh M. The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma. Am. J. Physiol. Renal Physiol. 2004 287 Fl-6. 

Czyzyk-Krzeska ME, Meller J. von Hippel-Lindau tumor suppressor not only HIE s executioner. Trends Mol. Med. 2004 10 147. 

Krieg M, Haas R, Branch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIE-1 alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000 19 5435-5443. 

Maynard MA, Ohh M. Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. Am J Nephrol 2004 24 1-13. 

Cherkasova E, Malinzak E, Rao S, Takahashi Y, Senchenko VN, Kudryavtseva AV, Nickerson ME, Merino M, Hong JA, Schrump DS, Srinivasan R, Linehan WM, Tian X, Lerman Ml, Childs RW. Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer. Oncogene. 2011 30 4697-706. 

The regulation of CXCR4 expression by factors known to be active in CNS tumors, such as Sonic hedgehog (Zhao et al, 2002), vascular ndothelial growth factor (Lee et al, 2002), the von Hippel-Lindau tumor suppressor pVHL (Staller et al., 2003), NF-kB (Helbig et al, 2003), and TNF-a... 

Na X, Wu G, Ryan CK et al. (2003) Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas. J Urol 170 588-592... 

II. The Role of the von Hippel-Lindau Tumor Suppressor in HIF Regulation... 

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Chfford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Hypoxia inducible factor-a binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 2000 275 25733-25741. 

Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG, Jr. Binding of the von Hippel-Lindau tumor suppressor protein to elongin B and C. Science 1995 269 1444-1446. 

Haase VH, Glickman, JN, Socolovsky M, Jaenisch, R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Nat Acad Sci USA 2001 98 1583-1588. 

Vaux EC, Wood SM, Cockman ME, Nicholls LG, Yeates KM, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. J Biol Chem 2001 276 44323 4330. 

Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell Biol 1999 19 1486-1497. 

Groulx I, Bonicalzi ME, Lee S. Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2. J Biol Chem 2000 275 8991-9000. 

Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP. The von Hippel-Lindau tumor suppressor gene product interacts with Spl to repress vascular endothelial growth factor promoter activity. Mol Cell Biol 1997 17 5629-5639. 

Tanimoto K, Makino Y, Pereira T, Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor N protein. EMBO J 2000 19(16) 4298-4309. 

Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner DR, Pause A. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci USA 1999 96 12436-12441. 

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