Ochrosia elliptica

Ochrosia elliptica Labill. (Bleekaria calocarpa Hassk.). According to Ray-mond-Hamet the pharmacological action of an aqueous extract of the bark of this species does not support the claim that the bark contains quinine though alkaloids are present. ((1) C.R. Soc. Biol., 1940, 133, 262. (2) Jacques, Un arbre k quinquina en NouveUe Caledonie, Noumea, 1937. (3) Greshoft, Meded. uit s Lands Planten, 1890, 7, 59 1898, 25, 130.)... 

The enzyme responsible for the stereospecific condensation of trypt-amine and secologanin 34) was called strictosidine synthase, and its presence was demonstrated by Treimer and Zenk 194) in a number of indole alkaloid-producing plants, including Amsonia salicifolia, Catharanthus roseus, Ochrosia elliptica, Rauwolfia vomitoria, Rhazya orientalis, Stem-madenia tomentosa. Vinca minor, and Voacanga africana. Enzyme activity as high as 1698 pkat/mg protein was observed for O. elliptica. No... 

Brafouedine (12) and isobrafouedine (13), two alkaloids isolated in minor amounts from the bark of the rhizome of Strychnos dintlagei (86JNP452), and Epchrosine (14), a metabolite of cell cultures Ochrosia elliptica Labill (86MI147, 86MI381), have similar structures. 

A. subincarnum, Bleekeria mdensis, Ochrosia elliptica (Apocynaceae)... 

Ellipticine (1) and 9-methoxyellipticine (2) have been isolated from Ochrosia acuminata stems (22) and from in vitro callus cultures derived from the stems of Ochrosia elliptica (23,24). It is found that the in vitro production of these alkaloids can be increased by cloning small cell aggregates. 

A fluorodensitometric assay was developed by Montague and co-workers 140) to analyze cultures from Ochrosia elliptica for ellipticine (1), 9-methoxy-ellipticine (2), and 9-hydroxyellipticine (3) by thin-layer chromatography (TLC) without the need for prior purification. Using silica gel impregnated with dimethyl sulfoxide and a mobile phase of EtOAc-water-l-octanol (17 2 2), these workers were able to achieve good separation of these alkaloids and to assay the resulting chromatograms by fluorodensitometry (40-300 fmol detection limits of alkaloid). 

Source Ochrosia elliptica. Biological activity Anti cancer. 

Ellipticine 9-Hydroxyellipticine Ochrosia elliptica Ochrosia elliptica 3940.00 4680.00 O. elliptica SC 0.005% DW... 

Ellipticine (41) and its 9-methoxy derivative (42) have great interest as antitumor dmgs. These alkaloids are isolated from the leaves of Ochrosia elliptica, a shmb found on scattered islands in the Indian and Pacific Oceans. Plant cell cultures would thus be of interest as an alternative means of production of the antitumor alkaloids. For a review on the genus, its alkaloids, and cell culture, the reader is also refered to Chenieux et al. (716). 

Ochrosia elliptica Catharanthine Vindoline Vinblastine Vincristine Vindesine Alioline Ellipticine... 

Olivacine (52) occurs in the bark of several Brazilian trees of the genera Aspidosperma and Tabernaemontana (Apocynaceae) ellipticine (53) and 9-methoxyellipticine (54) have been isolated from species of Ochrosia (Apocynaceae) (Neuss, 1980). Similar alkaloids have been isolated from Strychnos dinklagei (Gribble, 1990). Both ellipticine and 9-melhoxyellipticine (54) have been isolated at low levels from callus cultures of Ochrosia elliptica (Gribble, 1990). 

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