Vivo Genotoxicity Studies in Animals

No data were identified on the in vivo genotoxicity of JP-8 in animals other than the studies of Brusick and Matheson (1978b) discussed in the 1996 National Research Council report. 

Other jet fuels and related MDFs have been tested for genotoxicity in animals in vivo. Jet fuel A, administered by inhalation, induced chromosomal aberrations in the bone marrow of male and female Sprague-Dawley rats (Conaway et al. 1984, as reviewed by IARC 1989, Koschier 1999). McKee et 

API (American Petroleum Institute). 1984. Mutagenicity Evaluation Studies in the Rat Bone Marrow Cytogenetic Assay, in the Mouse Lymphoma Forward Mutation Assay Hydrodesulfurized Kerosene, API Sample 81-07. API Med. Res. Publ. 32-30240. Washington,DC American Petroleum Institute, Medicine and Biological Science Dept. 

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Genotoxicity. Occupationally exposed workers as well as patients injected with Thorotrast show chromosomal abnormalities in their lymphocytes. No in vivo genotoxicity studies in animals or in vitro studies in bacterial strains were located, but these studies may be useful in determining whether thorium has the potential to cause gene mutations in addition to chromosomal abnormalities. 

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