Vitamin interaction with thiamine

Thiamine pyrophosphate (TPP) (37), a derivative of vitamin Bi (38), contains two substituted heterocycles, the pyrimidine and thiazolium rings, connected by a methylene bridge. The reactive portion of this coenzyme is the thiazolium ring, the pyrimidine portion (as well as the pyrophosphate group) being important in binding interactions with proteins... 

Vitamin B complex is the collective term for a number of water-soluble vitamins found particularly in dairy products, cereals and liver.Vitamin B (thiamine) is used by mouth for dietary supplement purposes and by injection in emergency treatment of Wernicke-Korsakoff syndrome. Vitamin B2 (riboflavin) is a constituent of the coenzyme FAD (flavine adenine dinucleotide) and FMN (flavine mononucleotide) and is therefore important in cellular respiration. Vitamin Be (pyridoxine) is a coenzyme for decarboxylases and transamination, and is concerned with many metabolic processes. Overdose causes peripheral neuropathy. It may be used medically for vomiting and radiation sickness and for premenstrual tension. Pyridoxine has a negative interaction with the therapeutic use of levodopa in parkinsonism by enhancing levodopa decarboxylation to dopamine in the periphery, which does not then reach the brain. The antitubercular drug isoniazid interferes with pyridoxine, and causes a deficiency leading to peripheral neuritis that may need to be corrected with dietary supplements. Vitamin B ... 

The interaction of metal ions with vitamin Bi (thiamine hydrochloride, 135) continues to be of interest, and a combination of IR, XH and 13C NMR techniques have been applied to the... 

Thiamine is a monovalent cation with a structure that corresponds to a substituted pyrimidine bonded to a substituted thiazole. This structure leads to the presence of a quaternary N atom attached to the thiazole ring. Thus, thiamine - so-called vitamin Bl - exists as salts of the physiological chloride anion or one of a wide variety of other counter anions. For solubility reasons, thiamine is commercially available as its hydrochloride salt, namely thiaminium(2+) dichloride. The structures of thiamine metal complexes correspond to two groups those containing the divalent thiaminium cation and a cadmium complex as counterion, and those in which there is a direct cadmium-thiamine interaction. 

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