Virus picoma

Related picoma viruses such as human rhinoviruses (Fig. 7-15),69/78/79 foot-and-mouth disease virus, parvovirus,80 and Mengo virus81 have similar architectures. The small (diameter 25 nm) single-stranded DNA bacteriophages such as ( )X174 also have three different coat proteins, one of which forms small hollow spikes at the vertices of the icosahedral shell (Fig. 5-41A).82... 

Many viral RNAs that are formed within eukaryotic cells lack a 5 cap. They depend upon internal ribosomal entry sites (IRESs). This has been studied most with picoma viruses.338 502 503 These viruses not only initiate translation at discrete sites in uncapped RNA but carry out a proteolytic cleavage of initiation factor 4G (Fig. 29-11), which seems to be necessary for initiation of viral-RNA translation.338 504 The IRES... 

RE Lloyd, MJ Grubman, E Ehrenfeld. Relationship of p220 cleavage during picoma-virus infection to 2A proteinase sequencing. J Virol 62 4216-4223, 1988. 

Primary screening for antiviral activity was carried out using the agar-diffusion plaque-inhibition method with cylinders [65]. The compounds were tested against one representative in each of the four taxonomic viral groups namely, picoma-, orthomyxo-, paramyxo- and herpes viruses, which represent a few of the most important families of the human patogens. The viruses used were poliovirus 1 (PV1), influenza virus A (FPV), Newcastle disease virus (NDV) and pseudorabies virus (PsRV). 

Pleconaril is a broad spectrum anti-picoma virus agent [34], It is a small cyclic drug which binds to a canyon pore of the virus. In doing so it blocks the attachment and uncoating of the viral particle [35,36],... 

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