Virus erythrocytes, Sendai

Interestingly, erythrocytes that had lost (2—>3)-sialyl residues were still agglutinable by influenza viruses.531 In similar experiments with Madin-Darby, bovine kidney-cells and Sendai viruses, (2— 3)-sialyl residues as components of the oligosaccharide sequence a-Neu5Ac-(2— 3)-/3-Gal-(T 3)-GalNAc constitute specific receptors for these... 

Sendai virus, like other myxo- and paramyxovirus, has surface glycoprotein spikes which adsorb to specific receptors on erythrocytes of most mammalian and fowl species and cause hemagglutination. The receptors on erythrocyte membranes contain neuraminic acid, as indicated by the fact that they are destroyed by neuraminidase. Haywood (3 ) demonstrated that liposomes containing gangliosides could inhibit the agglutination of erythro-... 

Sendai virus attaches to erythrocytes, and to check that the wet spots really represented specifically bound virus it was in-... 

In a recent paper (3l) it was demonstrated that the removal of sialic acid from human erythrocytes with Vibrio oholerae sialidase abolished hemagglutination by Sendai virus. Hemagglutination titers were restored selectively by the incorporation of NeuAc with 8-galactoside a2-+3sialyltransferase which has a strict... 

The ability of the virus to agglutinate erythrocytes has been first reported in 1941. It took more than a decade before it was shown that influenza virus binds to erythrocytes and other cells via 7 -acetylneuraminic acid residues present on the cell surface and that this binding is a prerequisite for initiation of infection [24,25]. Other viruses, such as Sendai, Newcastle disease, polyoma and rotavirus also exhibit an affinity for sialie... 

Changes in the fluidity of erythrocyte membranes on binding influenza or Sendai virus have been ascribed to the interaction between the viral haem-agglutinin and a glycoprotein on the surface of the erythrocyte. ... 

Fuchs, P., and Giberman, E., 1973, Enhancement of potassium influx in baby hamster kidney cells and chicken erythrocytes during adsorption of parainfluenza (Sendai) virus, FEBS Lett. 31 127. 

Lyles, D. S., and Landsberger, F. R., 1977, Sendai virus-induced hemolysis Reduction in heterogeneity of erythrocyte lipid bilayer fluidity, Proc. Natl. Acad. Sci. USA 74 1918. 

Suzuki, Y., Suzuki, T., and Matsumoto, M., 1983, Isolation and characterization of receptor sialoglycoprotein for hemagglutinating virus of Japan (Sendai virus) from bovine erythrocyte membranes, J. Biochem. 93 1621-1633. 

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