Viral hemorrhagic fever syndrome

Rift Valley fever is characterized by high fever and the development of hemorrhagic areas under the skin. Only a small number of cases (<1%) go on to develop the more serious viral hemorrhagic fever syndrome that causes death in 50% of those who manifest this syndrome. The syndrome is associated with mucosal bleeding or hemorrhaging, liver and kidney failure, and shock before death. Some infections can be complicated with encephalitis and a variety of ocular defects.3... 

Hemorrhagic areas under skin Fewer than 1% develop more serious viral hemorrhagic fever syndrome leading to mucosal bleeding, liver and kidney failure, and shock before death... 

CLINICAL FEATURES OF THE VIRAL HEMORRHAGIC FEVER SYNDROME... 

Suggested Alternatives for Differential Diagnosis Leptospirosis, malaria, salmonella infection, lupus, typhoid fever, shigellosis, meningococcemia, yellow fever and other viral hemorrhagic fevers, rickettsial infections, thrombocytopenic purpura, acute leukemia, disseminated intravascular coagulation, hemolytic uremic syndrome. 

Ribavirin Interference with viral messenger RNA Lassa fever, hantavirus (hemorrhagic fever renai syndrome), hepatitis C (in chronic cases in combination with interferon a) 30-60... 

Ribavirin is a synthetic guanosine analogue, with in vitro activity against a broad spectrum of DNA and RNA viruses, and retroviruses, including HIV. Ribavirin has been used for treatment of a variety of viral infections, including respiratory syncytial virus bronchiolitis and pneumonia, measles, influenza types A and B, Lassa fever, hemorrhagic fever with renal syndrome (Hantaviruses), hepatitis C, and HIV infection. It is used commonly now along with interferon alpha for treatment of hepatitis C infection. There is no known direct nephrotoxicity of ribavirin. 

---