Vinorelbine tartrate

Vinca alkaloids and analogs vinblastine sulfate vincristine sulfate vinorelbine tartrate... 

Vindesine sulfate injection Vinorelbin tartrate injection Xylazine hydrochloride Zalcitabine... 

Bosque E. Possible drug interaction between itraconazole and vinorelbine tartrate leading to death after one dose of chemotherapy. Ann Intern Med 2001 134(5) 427. 

Feun LG, Savaraj N, Hmley J, Marini A, Lai S. A clinical trial of intravenous vinorelbine tartrate plus tamoxifen in the treatment of patients with advanced malignant melanoma. Cancer 2000 88(3) 584-8. 

Rittenberg CN, Gralla RJ, Rehmeyer TA. Assessing and managing venous irritation associated with vinorelbine tartrate (Navelbine) Oncol Nnrs Fornm 1995 22(4) 707-10. 

VInorelbine Tartrate. Vinorcibine tartrate. Navelbinc. is a new scmisynthctic vinca alkaloid derived from vinblastine by loss of one carbon from ring C and dehydration in ring D. both in the catharanthine moiety. It is named 3. 4 -didehydro-4 -dcoxy-C -norvincalcukoblastinc. Navcibine is supplied in vials containing 10 mg/mL of solution in a volume of I mL of Water for Injection or 10 mg/mL of solution in a volume of 5 mL of Water for Injection. Unopened vials are stable at room temperature fur up to 72 hours. It is diluted to a concentration of 0.5 In 2 mg/mL with 0.9% Sodium Chloride Injection or 5% Dextrose Injection for intravenous infusion or slow intravenous push administration. 

Naiurctin. See Bendroflumcihiazide Navane. See Thiothixene Navelbine. See Vinorelbine tartrate Ncnminc. 338... 

Doxil - liposomal doxorubicin Navelbine - vinorelbine tartrate Uromitexan - mesna... 

Vinorelbine tartrate (Fig. 42.35) is used alone or in combination with cispiatin for first-line treatment of nonsmall cell lung cancer. This semisynthetic alkaloid is unique in having oral bioavailability (85), but it currently is available only for IV injection. The initial phase elimination half-life is on par with that observed for vincristine and vinblastine, and the terminal phase half-life is between 28 and 44 hours. Although dose-limiting granulocytopenia is the major adverse effect, potentially fatal interstitial pulmonary changes have been noted, and patients with symptoms of respiratory distress should be promptly evaluated. As with all vinca alkaloids, elimination is primarily hepatobiliary, and dosage reduction should be considered in patients with liver dysfunction. 

Navelbine (Vinorelbine tartrate). Pierre Fabre Pharmaceuticals Inc. US Prescribing information, August 2005. 

UoshimaN, Yoshioka K, T )shi J, Wada S, Fujiwara Y. Acute respiratory failure caused hy vinorelbine tartrate in a patient with non-small cell lung cancer. Intern Med(2001) 40, TT9-82. 

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