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Vinblastine Phenobarbital

P-gp (ABCB1) Verapamil, digoxin, mitoxantrone, vinblastine, doxorubicin, losartan, talinolol, cortisol, dexamethasone, colchicine, loperamide, domperidone, indinavir, erythromycin, tetracycline, itraconazole, cyclosporine, methotrexate, amitryptyline, phenobarbital, morphine, cimetidine, and others... [Pg.7]

Azathioprine, chloramphenicol, colchicine, cyclophosphamide, cytarabine, 5-fluorodeoxyuridine, 5-fluorouracil, hydroxyurea, mercaptopurine, metformin, methotrexate, phenobarbital, phenytoin, primidone, proton pump inhibitors, pyrimethamine, sulfasalazine, and vinblastine... [Pg.120]

Mercaptopurine Methotrexate Oral contraceptives p-Ami nosalicylate Phenobarbital Phenyloin Primidone Pyrimethamine Sulfasalazine Tetracycline Vinblastine... [Pg.960]

VINCA ALKALOIDS - VINBLASTINE, VINCRISTINE 1. ANTIBIOTICS-rifampicin 2. ANTICANCER AND IMMUNOMODULATING DRUGS - dexamethasone 3. ANTIDEPRESSANTS-St John s wort 4. ANTI EPILEPTICS -carbamazepine, phenobarbital, phenytoin 1 of plasma concentrations of vinblastine and vincristine, with risk of inadequate therapeutic response. Reports of 1 AUC by 40% and elimination half life by 35%, and t clearance by 63%, in patients with brain tumours taking vincristine, which could lead to dangerously inadequate therapeutic responses Due to induction of CYP3A4-mediated metabolism Monitor for clinical efficacy, and t dose of vinblastine and vincristine as clinically indicated in the latter case, monitor clinically and radiologically for clinical efficacy in patients with brain tumours and t dose to obtain desired response... [Pg.342]

Drugs that are known to be substrates of P-gp include antihistamines (e.g. terfenadine), digoxin, ciclosporin, hydrocortisone and other steroids and drugs used in chemotherapy (e.g. paclitaxel, vinblastine). Ciclosporin, in addition to being a substrate of P-gp, is also an inhibitor of P-gp. Drugs known to induce P-gp include morphine, dexamethasone, phenobarbital, rifampin and St John s wort. Inhibitors of P-gp include amiodarone, amitriptyline, atorvastatin, chlorpromazine, ciclosporin, erythromycin, fluphenazine, haloperidol, quinidine, ritonavir and verapamil,... [Pg.858]

Clinically important, potentially hazardous interactions with alprazolam, amphotericin B, anisindione, anticoagulants, dicumarol, eplerenone, erythromycin, methadone, midazolam, phenobarbital, phenytoin, ramelteon, sulfonylureas, trabectedin, vinblastine, vincristine, warfarin... [Pg.235]

Phenytoin Phenobarbital Vinblastine Carmustine Methotrexate Lung cancer with brain metastases Phenytoin ieveis feii from 9.4 to 5.6 micrograms/mL 24 hours after vinblastine. Patient fitted. Phenytoin ieveis returned to normai 2 weeks after chemotherapy. Phenobarbitai ieveis unaffected. 4... [Pg.519]

See other pages where Vinblastine Phenobarbital is mentioned: [Pg.604]    [Pg.697]    [Pg.697]    [Pg.496]    [Pg.49]    [Pg.60]    [Pg.189]    [Pg.205]    [Pg.228]    [Pg.384]    [Pg.403]    [Pg.460]    [Pg.489]    [Pg.622]    [Pg.745]    [Pg.801]    [Pg.842]    [Pg.888]    [Pg.933]    [Pg.1002]    [Pg.1047]    [Pg.1142]    [Pg.1172]    [Pg.1190]    [Pg.1373]    [Pg.1450]    [Pg.1467]    [Pg.1492]    [Pg.49]    [Pg.60]    [Pg.189]    [Pg.205]    [Pg.228]    [Pg.384]    [Pg.403]    [Pg.460]    [Pg.489]    [Pg.622]    [Pg.745]    [Pg.801]   
See also in sourсe #XX -- [ Pg.518 ]



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