Vesicles budding and fusion

Bonifacino JS, Glick BS (2004) The mechanisms of vesicle budding and fusion. Cell 116 153-166... 

Protein trafficking is the transport of proteins to their correct subcellular compartments or to the extracellular space ( secretory pathway ). Endo- and exocytosis describe vesicle budding and fusion at the plasma membrane and are by most authors not included in the term protein trafficking. Protein quality control comprize all cellular mechanisms, monitoring protein folding and detecting aberrant forms. 

J.E. Rothman, The protein machinery of vesicle budding and fusion, Protein Sci. 1996, 5,185-194. 

Budding and fusion of ER-to-Golgi vesicles to form c/s-Golgi... 

F. M. Menger, N. Balachander, Chemically-induced aggregation, budding, and fusion in giant vesicles - direct observation by light-microscopy, J. Am. Chem. Soc, 1992, 114, 5862-5863. 

The kinetic control of vesicle transport, from vesicle budding in the Golgi (and other origins) to fusion of the vesicle with the target membrane, is currently a vigorous area of research. The formation of COP-coated vesicles... 

Protein transport between intracellular compartments is mediated by a mechanism that is well-conserved among all eukaryotes, from yeast to man. The transport mechanism involves carrier vesicles that bud from one organelle and fuse selectively to another. Specialized proteins are required for vesicle transport, docking, and fusion, and they have been generically named SNAREs (an acronym for soluble N-ethylma-leimide-sensitive fusion attachment protein receptor). SNAREs have been divided into those associated with the vesicle (termed v-SNAREs), and those associated with the target (termed t-SNAREs). The key protein, which led to the discovery of SNAREs was NSF, an ATPase found ubiquitously in all cells, and involved in numerous intracellular transport events. The subsequent identification of soluble proteins stably bound to NSF, the so-called SNARE complex, led to the formulation of the SNARE hypothesis, which posits that all intracellular fusion events are mediated by SNAREs (Rothman, 2002). 

Sollner.T. H., and Rothman, J. L. 1996. Molecular machinery mediating vesicle budding, ducking and fusion. Experientia 52 1021-1025. 

Rab proteins exist in all cells and form the largest branch of the Ras superfamily. This family performs a central function in vesicular transport. Rab proteins influence and regulate the budding, targeting, docking and fusion of vesicles as well as processes of exocytosis and endocytosis involving clathrin-coated vesicles. During these functions, Rab proteins cycle between the cytosol and the cell membrane, and this cyle is superimposed on a GDP/GTP cycle. The cytosolic pool of the Rab pro-... 

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