Vesicles associated protein

Hilton, J. M., Plomann, M., Ritter, B. etal. Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase. J. Biol. Chem. 276 16341-16347,2001. 

Zhang, Y., et al.. Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1 [In Process Citation]. Proc Natl Acad Sci USA,... 

De Camilli P, Thomas A, Cofiell R, Folli F, Lichte B, Piccolo G, et al. The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer. J Exp Med 1993 178(6) 2219-2223. 

Potential Roles of Synaptic Vesicle Associated Proteins in the Etiology of Schizophrenia. 277... 

In this chapter, we will review the evidence suggesting a role for specific synaptic vesicle-associated proteins in schizophrenia. First, we present a brief overview of the synaptic vesicle cycle in the broader context of synaptic neurotransmission at chemical synapses. We then describe the experimental evidence linking specific molecular components of the synaptic vesicle to schizophrenia. Since not all synaptic vesicle proteins have been studied in relationship to schizophrenia, this review focuses only on those proteins for which such an effort was made. Finally, we describe the potential roles these proteins could play in the context of current etiological theories of schizophrenia, and discuss the relevance of the experimental findings in the context of this enigmatic disorder. 

What potential roles could synaptic vesicle associated proteins have in the context of two major theories regarding the etiology of schizophrenia, namely the synaptic hypothesis and the neurodevelopmental hypothesis ... 

It may be useful to consider the different types of evidence linking specific synaptic vesicle-associated proteins with schizophrenia (Q Table 2.4-2). The evidence implicating some proteins, such as synapsin III, SNAP-25, and complexins, in schizophrenia has been accumulated at postmortem, genetic, and behavioral levels. 

Although we have discussed specific synaptic vesicle-associated proteins in this chapter, it is important to recognize that these proteins do not function alone. Extensive protein-protein interactions are required for the orchestrated release of neurotransmitter at the synaptic cleft. SNARE proteins form a complex that must interact with synaptotagmins, synaptophysin, and other molecules for fusion and exocytosis to occur. Synapsins bind to multiple signaling molecules as well as the synaptic vesicle and actin, in order to... 

Burgoyne RD (1990) Secretory vesicle-associated proteins and their role in exocytosis. In Anna. Rev. Physiol. 52 647-59. 

As this is written (1996), it is fair to say that science does not know the structure of the receptors for either botulinum or tetanus toxins. A report published in 199426 suggesting that a synaptic vesicle-associated protein called synaptotagmin may be the receptor for botulinum toxin serotype B. This intriguing work has yet to be confirmed, and... 

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