Ventilatory capacity

Complicated pneumoconiosis (PMF) is associated with a reduction in ventilatory capacity, low diffusing capacity, abnormalities of gas exchange, low arterial oxygen tension, pulmonary hypertension, and premature death ... 

In human subjects, concentrations of about 5mg/m were objectionable, usually causing cough, with an increase in respiratory rate and impairment of ventilatory capacity. ... 

Vallebona A, Gigli G, Orlandi S, Reggiardo G. Heart rate response to graded exercise correlates with aerobic and ventilatory capacity in patients with heart failure. Clin. Cardiol. 2005 28 25-9. 

Lung function. Exposure of six men to barley dust for 2 days decreased ventilatory capacity. Five volunteers not previously exposed to barley dust, when exposed to the dust for 2 hours, decreased the ventilatory capacity ranging from 200 mL to 800 mL, with recovery taking up to 72 hours. All of the subjects had decreases in flow at 50% vital capacity hut little or no change in flow at 75% vital capacity. In three subjects, there was a drop in specific conductance... 

In patients with chronic airways obstruction salmefamol (5) gave greater response than 4, particularly 6 to 8 hr. post dose.24<2 Orally (2 mg) 5 caused a fall in diastolic blood pressure, whereas 1 mg dose did not, and both were found equally effective on ventilatory capacity.2 By inhalation fenoterol (6) was equipotent with 4 in the treatment of asthmatic children but caused some increases in pulse rate.2 Orally, 6. caused significant bronchodilatation with rapid onset (30 min.) and long duration (6 hrs.) but showed mild tremors and increased pulse rates at higher doses (15, 20 mg).28 Carbuterol (7) (SKF 40383) in a double-blind study produced safe and effective bronchodilatation both orally (4 mg) and by inhalation28 (300 jug), but was less potent than 4. ... 

Gandevia, G. Studies ov ventilatory capacity and histamine response during exposure to isocyanate vapour in polyurethane foam manufacture. Br J Ind Med 20 204-09, 1963. 

CHRONIC HEALTH RISKS chronic bronchitis emphysema simple pneumoconiosis slight cough blackish sputum decreased pulmonary function complicated pneumoconiosis reduction in ventilatory capacity low diffusing capacity low arterial oxygen tension pulmonary hypertension premature death. 

Rastogi SK, Gupta BN, Husain T, Mathur N, Pangtey BS, Garg N (1992) Respiratory symptoms and ventilatory capacity in metal polishers. Hum Exp Toxicol 11 466-472... 

Pnlmonary function tests Measurement of ventilatory capacity of the Inng by a series of tests, such as forced expiratory volume (FEV) and forced vital capacity (FVC). 

Spirometry is the measurement of the ventilatory capacity of the lungs. Forced vital capacity (FVC) is the maximum volume of air that can be exhaled forcefully after a maximum inspiration. 

Acute exacerbations superimposed on advanced chronic disease require the effective administration of noninvasive ventilation (NIV) to improve morbidity and mortality. NIV should also enable a steady improvement in spontaneous ventilatory capacity. A decrease in partial pressure of carbon dioxide in arterial blood (Paco2) during ventilation and subsequently during unassisted respiration is the best indicator of effective NIV (1,2). 

Patients with NMD can be extubated to NIPPV despite little or no autonomous ventilatory capacity. Postextubation CPF is a good predictor of successful extubation as it reflects bulbar-innervated muscle integrity, and therefore, the ability to eliminate airway secretions (10,11). Preextubation peak expiratory flows have also been shown to predict success in extubating patients with primarily respiratory impairment (28). 

Williams MK. Sickness absence and ventilatory capacity of workers exposed to sulfuric acid mist. Br J Ind Med 1970 27 61. 

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