UTP-glucose-1 -phosphate

ATP + nicotinamide mononucleotide DPN + pyrophosphate or UTP + glucose-1-phosphate UDP-glucose -f- pyrophosphate... 

Uridine triphosphate (UTP) + Glucose-1-phosphate pytophl phorylas Uridine diphosphate glucose (UDPG) + Pyrophosphate... 

In animal tissues the synthesis of UDPGlc from UTP and glucose-1-phosphate is catalysed by a pyrophosphorylase of widespread occurrence. With the enzyme from human liver, there is no specificity for either the... 

Frc-6-P = fructose-6-phosphate Glc-1-P = glucose-1-phosphate PPP = pentose phosphate pathway UTP = uridyl triphosphate... 

The formation of glycosidic bonds between sugars is endergonic. Initially, therefore, the activated form—UDP-glucose—is synthesized by reaction of glucose 1-phosphate with UTP (see p. 110). 

This enzyme [EC 2.7.7.10], also known as UTP hexose-1-phosphate uridylyltransferase, catalyzes the reaction of UTP with a-D-galactose 1-phosphate to produce UDP-galactose and pyrophosphate (or, diphosphate), a-o-Glucose 1-phosphate can also function as a substrate, albeit not as effectively. 

This enzyme [EC 2.7.7.9] catalyzes the UTP-dependent uridylylation of a-o-glucose 1-phosphate that yields UDP-glucose and pyrophosphate. 

UTP a-D-glucose 1-phosphate uridyltransferase CMP-acetylneuraminic acid synthetase... 

UDP-glucose pyrophosphorylase catalyzes the synthesis of UDP-glucose (see Fig. 1) from UTP and glucose 1-phosphate ... 

Sarciron, M. E., Azzar, G., Persat, F., Petavy, A.-F. Got, R. (1987). A comparative study of UTP-D-glucose-1-phosphate uridylyl transferase in the cysts of Echinococcus multilocularis and the livers of infected and control Meriones unguiculatus. Molecular and Biochemical Parasitology, 23 25-9. 

The glucose 1-phosphate is then activated to enable its incorporation into glycogen. This activation involves the expenditure of energy derived from the hydrolysis of a molecule of uridine triphosphate (UTP) by UDP-glucose pyrophosphorylase. 

One is from glucose 1-phosphate and the other is from uridine monophosphate (UMP). The pyrophosphate that is liberated from the terminal phosphates of UTP is hydrolyzed to inorganic phosphate by the enzyme pyrophosphatase. This hydrolysis, which is irreversible, drives the reaction in the direction of UDP-glucose synthesis. 

UDP-glucose is synthesized from glucose 1-phosphate and uridine triphosphate (UTP) in a reaction catalyzed by UDP-glucose pyrophosphorylase. The pyrophosphate liberated in this reaction comes from the outer two phosphoryl residues of UTP. 

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