US,NATIONAL TOXICOLOGY PROGRAM

BREVET INC. VINYL INSTITUTE US,NATIONAL TOXICOLOGY PROGRAM... 

US National Toxicology Program (NTP). Online. Available HTTP (accessed 1 April 2003). 

The US National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences (NIEHS) have established the NTP Center for the Evaluation of Risks to Human Reproduction in 1998. The Center provides scientifically based, uniform assessments of the potential for adverse effects on reproduction and development caused by agents to which humans may be exposed. 

Stability Sensitive to light, especially ultraviolet light, and undergoes relatively rapid photolytic degradation (US National Toxicology Program, 1998)... 

An example of this type of a safer chemical is methacrylonitrile (1) compared with acrylonitrile (2) (Figure 1.1). Both compounds are a, 3-unsaturated aliphatic nitriles, and structurally very similar, but 2 causes cancer whereas 1 does not appear to do so. Among other applications, 2 is used in the production of acrylic and modacrylic fibers, elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, and gas barrier resins. In a study conducted by the US National Toxicology Program (NTP) in which 2 was administered orally to mice for 2 years, there was clear evidence that it caused cancer in the treated mice (in addition to causing other toxic effects), and is classified by the NTP as a probable human carcinogen [26]. 

SAS, Salmonella typhimurium TA97. reverse mutation — — 1667 US National Toxicology Program (1989)... 

Bakale, G. and McCreary, R.D., Prospective Ke screening of potential carcinogens being tested in rodent bioassay by the US National Toxicology Program, Mutagenesis, 7, 91-94, 1992. 

Benigni, R., QSAR prediction of rodent carcinogenicity for a set of chemicals currently bioassayed by the US National Toxicology Program, Mutagenesis, 19, 83-89, 1991. 

Benigni, R., The first US National Toxicology Program exercise on the prediction of rodent carcinogenicity definitive results, Mutation Res., 387, 35 -5, 1997. 

Bootman, J., Speculations on the rodent carcinogenicity of 30 chemicals currently under evaluation in rat and mouse bioassays organised by the US National Toxicology Program, Environ. Mol. Mutagenesis, 27, 237-243, 1996. 

Rosenkranz, H.S. and Klopman, G., Prediction of the carcinogenicity in rodents of chemicals currently being tested by the US National Toxicology Program structure-activity correlations, Mutagenesis, 5, 425 132, 1990. 

Cumene is being tested for carcinogenicity by inhalation in rats and mice by the US National Toxicology Program reports are not available. Cumene is not expected to be a genotoxic carcinogen. 

The US National Toxicology Program (NTP) has converted study reports into an electronic format which can be accessed freely from the Web site (http //ntp-apps.niehs.nih.gov/ntp tox/index.cfin). 

This Standard contains detailed criteria for health hazards and a carcinogenic hazard must be mentioned if the substance has been assessed as a carcinogen by the International Agency for Research on Cancer (lARC), the US National Toxicology Program (NTP) or OSHA. 

A large body of literature on health effects of lead exposure and faetors that influence lead toxicity has been published sinee the 1978 OSHA standard was established. Most recently, the US National Toxicology Program (NTP) released a monograph on the health effects of low-level lead exposure, defined by the NTP as BLLs of under 10 gg/dL and in some eases under 5 gg/dL. The... 

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