Ursolic acid from

Other sorts of NO inhibitors are triterpenes, such as ursolic acid and 2-a-hydroxy ursolic acid and 2-a-hydroxy ursolic acid from Prunella vulgaris L., inhibit the production of NO by murine leukaemic monocyte macrophage cells, RAW 264.7, cultured in vitro. The IC50 values were 17 xM for ursolic acid and 27 jxM for 2-a-hydroxy ursolic (51). 

Kams, and P. W. Geno. Isolation and CA097 characterization of ursolic acid from Coffea arabica L. (coffee) leaves. 

Oleanolic acid Cormis officinalis Sieb.et Zucc/Cornaceae Seeds Isolated together with ursolic acid from C.officinalis, this compound decreased the water consumption and urine volume in diabetic rats [62J. 

Earlier, we have reported the bioactivity of kaempferitrin and ursolic acid from H. verticillata against brine shrimp larvae. Both compounds were found to be toxic with LC50 = 21.9 ppm and 29.8... 

Ibragimov AYa, Khazanovich RL (1972) Ursolic acid from Agrimonia asiatica. Chem Nat Compd 8(3) 390-391 Ibragimova MU, Israilov lA, Yunusov MS, Yunusov SYu (1974) Alkaloids of Fumaria vaillantii structure of vadlantine. Chem Nat Compd 10(4) 481 82... 

In therapeutic doses, Cg. have long been used to strengthen the contraction of heart muscle. Higher doses are toxic. They bind to specific membrane receptors, which are thought to be part of the NaVK -ATPase complex. Endogenous compounds binding to the same receptors ( ouabain-like compounds or OLC) have been purified from several sources. [Y.Shimoni etal. Nature 307 (1984) 369-371 F.Abe etal. Presence of Cardenolides and Ursolic Acid from Oleander leaves in Larvae and Frass of Daphnis nerii Phytochemistry 42 (1996) 51-60]... 

Frighetto RTS, Welendorf RM, Nigro EN, Frighetto N, Siani AC (2008) Isolation of ursolic acid from apple peels by high speed counter-current chromatography. Food Chem 106 767-771... 

Segelman AB, Farnsworth NR 1974 Catharanthus alkaloids. XXXI. Isolation of ajmalicine, pericalline, tetrahydroalstonine, vindolinine and ursolic acid from Catharanthus trichophyllus roots. J Pharm Sci 63 1419-1422... 

Investigating the most abundant bioaetive compounds from Cornus mas fruits, Jayaprakasam and co-workers reported the isolation of 2.2 g ursolic acid from 8 kg fruit pulp after sueeessive extraetions with w-hexane, ethyl acetate and methanol followed by column chromatography purification of the product [Jayaprakasam et al., 2006]. 

Ursolie aeid is eonsidered one of the most promising chemopreventive agents for cancer, based on investigation of its antitumor activies [Kassi et al., 2007]. Kwon and co-workers tried to elucidate the apoptotic mechanism of ursolic acid from Comi Fructus in primary human malignant prostate tumor cells, proving that this eompound inhibit prostate cancer cell growth [Kwon et al., 2010]. 

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