Urinary components, molecular

Changes in the molecular weight distribution of urinary components were examined by chromatography of urine (3 ml) on Sephadex G-25 columns (2.5 x 40 cm) with 0.1 M phosphate buffer, pH 8 (5). The resulting fractions were hydrolyzed with HC1 and reacted with ninhydrin (5). Absorbance was determined at 570 nm. 

As with DEHP, other oxidative metabolites of DiNP are probably the most abundant urinary metabolites [141]. Because DiNP is a complex mixture, MiNP may not reflect total exposure to all DiNP components. Thus, low molecular weight phthalates... 

Inoue, O., Seiji, K., Kudo, S., Jin, C., Cai S.-X., Liu, S.-J., Watanabe, T., Nakatsuka, H. Ikeda, M. (1995) Urinary phenylglyoxylic acid excretion after exposure to ethylbenzene among solvent-exposed Chinese workers. Int. J. occup. environ. Health, 1, 1-8 Johnstone, R.A.W., Quan, P.M. Carmthers, W. (1962) Composition of cigarette smoke some low-boiling components. Nature, 195, 1267-1269 Jonsson, A., Persson, K.A. Grigoriadis, V (1985) Measurement of some low molecular-weight oxygenated aromatic and chlorinated hydrocarbons in ambient air and in vehicle emissions. Environ, int., 11, 383-392... 

A venerable drug used for the disinfection of acidic urine, methenamine is a low-molecular-weight polymer of ammonia and formaldehyde that reverts to its components under mildly acidic conditions. Formaldehyde is the active antimicrobial component. Methenamine is used for recurrent urinary tract infections. The drug is available in various dosage forms as well as various salts, including the hippurate and mandelate. 

The urine of a mammal is a rich source of organic compounds that may range in molecular mass from components as large as proteins to relatively small molecules (<100 D of mass), presumably various secondary metabolism products. On a less absolute scale, volatility of various urinary metabolites will be limited by both their molecular mass and polarity. Based on the presence of polar and ionizable groups in the molecule, some very small molecules (e.g., urinary acids, peptides or carbohydrates) are very unlikely to... 

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