Uridine-5 diphosphogalactose

Heidlas JE, Lees WJ, Whitesides GM. Practical enzyme-based syntheses of uridine 5 -diphosphogalactose and uridine 5 -diphospho-A-acetylgalactosa-mine on a gram scale. J Org Chem 1992 57 152-157. 

For preparation of D-galactopyranosyl (l- 4)-2-acetamido-2-deoxy- -Dglucopyranosyl-(l- 0)-elymoclavine (32) the extension of previously prepared 2-acetamido-2-deoxy- -D-glucopyranosyl-(l- O)-elymoclavine (31) by the use of bovine -1,4-galactosyltransferase was chosen. Uridine 5 -diphosphogalactose (UDP-Gal) served as a substrate (Kfen etat., 1994b). 

Taki T, Ogura K, Rokukawa C, Hara T, Kawakita M, et al. Had-1, a uridine 5 -diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A composition of glycolipids, cell growth inhibition by lactosylceramide, and loss of tumorigenicily. Cancer Res. 1991 57 1701 1707. 

K8. Kalckar, H. M., Braganca, B., and Munch-Petersen, A., Uridyl transferases and the formation of uridine diphosphogalactose. Nature 172, 1038 (1953). 

M3. Maxwell, E. S., The enzymic interconversion of uridine diphosphogalactose and undine diphosphoglucose. J. Biol. Chem. 229, 139-151 (1957). 

R2. Robichon-Szulmajster, H. de, Sur un nouveau mecanisme d oxydo-reduction, appliqu6 a la reaction d epimerisation uridine diphosphogalactose = uridine diphos-phoglucose. J. Mol. Biol. 3, 253-256 (1961). 

Seyama, Y., Kalckar, H. M. Specific tritium labeling of uridine diphosphogalactose 4-epimerase by d-1-3H Galactose. Biochemistry 11, 36—39 (1972). 

Chacko CM, McCrone L, Nadler HE. Uridine diphosphoglucose pyropho-sphorylase and uridine diphosphogalactose pyrophosphorylase in human skin fibroblasts derived from normal and galactosemic individuals. Biochim Bio-phys Acta, Enzymol 1972 268 113-120. 

Gastinel, L.N., Cambillau, C. and Bourne, Y. Crystal structures of the bovine p4galactosyl-transferase catalytic domain and its complex with uridine diphosphogalactose. EMBO J. 1999,... 

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