Uridine-diphosphoglucose

Isselbacher, K. J., cited by Kalckar, H. M., and Maxwell, G. S., Biosynthesis and metabolic function of uridine diphosphoglucose in mammalian organisms and its relevance to certain inborn errors. Physiol. Revs. 38, 88 (1958). 

Maxwell, E. S. The enzymic interconversion of uridine diphosphogalactose and uridine diphosphoglucose. J. Biol. Chem. 229, 139—151 (1957). 

Haloperidol is a butyrophenone neuroleptic drug. The enzymes involved in its biotransformation include oxidative cytochrome P450 isozymes, carbonyl reductase, and uridine diphosphoglucose glucuronosyltransferase (1). It is mainly cleared by glucuronidation. 

Davies, M.D., and Dickinson, D.B., 1972, Properties of uridine diphosphoglucose dehydrogenase from pollen of Lilium longiflorum. Arch. Biochem. Biophys. 152 53-61. 

The Vhp and Jcp couplings of uridine diphosphoglucose have been measured under a variety of conditions by du Penhoat and co-workers. ... 

B-D-Glucosyltransferase, uridine diphosphoglucose-flavonol 3-0-glucoside 429b, 4249... 

Glucosyltransferase, uridine diphosphoglucose-fructose phosphate 429b, 4249, 4489... 

Chacko CM, McCrone L, Nadler HE. Uridine diphosphoglucose pyropho-sphorylase and uridine diphosphogalactose pyrophosphorylase in human skin fibroblasts derived from normal and galactosemic individuals. Biochim Bio-phys Acta, Enzymol 1972 268 113-120. 

Fig. 11.1.4. Separation of uracil and 5-fluorouracil bases, nucleosides and nucleotides by reversed phase ion-pair HPLC. Chromatographic conditions column, Bondapak Cig (300 x 4 mm) mobile phase, (from 0-30 min) 0.1 mM tetrabutylammonium hydrogen sulphate (Cjg), 2.5 mM tetraethylammonium bromide (Cg) and 2% methanol in 2 mM sodium acetate, 1.5 mM phosphate buffer, pH 6.0 (Buffer A) (from 30-50 min) Buffer A-i-30 mM phosphate detection, UV at 254 nm. Peaks FU, fluorouracil FUR, fluorouracU riboside/ FUdR, fluorouracil deoxyriboside FUMP, fluorouridine 5 -monophosphate 5 dFUR, 5 -deoxyfluorouracil riboside FdUMP, deoxyfluorouri-dine monophosphate UDPG, uridine diphosphoglucose UDP, uridine diphosphate dUDP, deoxyuridine monophosphate UTP, uridine triphosphate. Reproduced from Au et al. (1982), with permission.

---