Update to chapter

Since the time of writing a number of advances have been reported which further extend the scope and usefulness of the M13 cloningsequencing procedures described in Chapter 4. These are described under the separate headings below and are cross-referenced to Chapter 4. 

The 26 base pair universal primer isolated from phage pSP14 (Anderson et al. Nucleic Acids Res. 8, 1731-43 (1980), cf. Section 4.3.7, Fig. 4.11), is available from Bethesda Research Laboratories. 

---

I would like to thank Dr. Cynthia Randall of Sanofi Pharmaceuticals not only for an excellent contribution in the field of ion exchange chromatography presented as an update to Chapter 5, but also for substantial assistance in tracking down literature. Without her help and encouragement, the second edition would not have become reality. Thanks are also due to Denise Lawler, without whose help family obligations would have made this work impossible. 

This chapter is an update to Chapter 8.04 of CHEC-II(1996) <1996CHEC-II(8)95> it covers the literature from 1995 to 2007. More specifically, it contains major informations on the preparation and reactivity of these bicyclic 5-5 systems. Furthermore, a variety of biological activities and important applications in the chemical, medical, and agrochemical field beyond the scope of this chapter. Considering the little information obtained in few areas, coverage of sections dealing with structural, theoretical and thermodynamic data has been kept to a minimum since only imidazo[l,2- ]imidazole and imidazo[l,2- ]pyrazole systems have been the subject of recent studies. The most important structural data have already been summarized in CHEC-II(1996), Chapter 8.04. 

Longo, D.L., 2002 Update to Chapter IIV. Acute and chronic myeloid leukemia, Harrison s Online (www.harrisonsoniine.com), the McGraw-Hill Companies. 

In order to keep this reference work as useful and fresh as possible, our plan from the start was to provide supplementary volumes on a periodic basis. These would contain updates to chapters on topics where there is substantial recent progress, and new chapters on emerging topics. We are delighted to provide you here with the first of these supplements. 

Where current practice seemed to dictate I updated curves, and added a table in Chapter 4 to help with the sizing of the oil-free helical lobe-compressors. Instrumentation was updated to take rod-drop monitoring of reciprocating compressors into consideration. Improvements in torque monitoring are also included. 

Another interesting aspect of this requirement is that the implementation of changes is to include updates to all appropriate documents. This means that the impact of a customer change order on your internal documents needs to be evaluated and the corresponding changes made to all affected documents. This should be performed as part of the change review process (see later in this chapter). 

Chapter 14, Mechanical Drivers, has been updated to inlcude the latest code and standards of the National Electrical Manufacturer s Association and information on the new energy efficient motors. 

With one exception, all the chapters from the third edition of Modern Pharmaceutics that appear in the fourth edition have been revised and updated. Many chapters were extensively updated, and some, such as the first and last chapters, were extensively rewritten. Due to the illness of Dr. Robinson, the chapter on sustained and controlled release drug delivery systems was updated with the assistance of Gil Banker, with Dr. Robinson s approval. 

This chapter covers the literature from 1995 to the present and updates earlier chapters in this series <1984CHEC(5)880, 1984CHEC(5)860, 1996CHEC-II(8)465>. 

Rearrangement reactions have greatly interested chemists for a long time (a) from the synthetic viewpoint as routes to new compounds and (b) from the mechanistic viewpoint, in order to discover how these reactions occur. This chapter is intended to update previous chapters in this series. No attempt has been made to be comprehensive in the treatment, and the effort has centred on new developments, particularly of understanding mechanisms, rather than on reporting additional examples of reaction types already known. Rearrangement reactions are constantly being reviewed the most complete account is in... 

Most of the chapters have been updated to reflect the increased body of knowledge in the respective areas of unit operations. The sections on scale-up of granulation and tableting have been completely revised. New sections have been added, namely, on the scale-up of roller compaction, extrusion, and hard gelatin encapsulation. 

As can be expected, the creation of the Third Edition allowed for further improvements in the readability of the text and for the correction of inaccuracies appearing in earlier editions. Content changes were also made. The most significant of these changes include a reworking of the presentation of the scientific method as found in Chapter 1. For Chapter 9, the section on entropy was greatly revised. For Chapter 10, Lewis acids and bases are now discussed, and for Chapter 17 a new section on gas laws was added. The topical chapters of this textbook, Chapters 13—19, were also updated to reflect current events. 

It is now 13 years since the appearance of Volume 1 of Advances in Heterocyclic Chemistry, and significant progress in many of the subjects covered in the early volumes of the series has been made since publication. We have therefore embarked on the policy of updating appropriate chapters, and three of the articles in the present volume are of this type. Adrien Albert has written an account of the progress of covalent hydration since its first appearance in Volume 4. P. Tomasik and C. D. Johnson have reported on progress in the application of the Hammett equation to heterocycles since the Jaffe and Lloyd Jones article in Volume 3, and A. Holm has similarly taken on the account of 1,2,3,4-thiatriazoles given by Jensen and Pedersen in the same volume. 

Apart from general updating and correction, the main alterations in the second edition of Volume 3 are additions to Chapter 1 on Reactor Design and the inclusion of a Table of Error Functions in the Appendix. 

---