Ciechanover, Aaron

John Mayer, Aaron Ciechanover, Martin Rechsteiner (Eds.)... 

Aaron Ciechanover Marty Rechsteiner John Mayer... 

Aaron Ciechanover Israel discovery of ubiquitin-mediated protein degradation... 

Aaron Ciechanover, Hedva Gonen, Beatrice Bercovich, Shai Cohen,... 

Aaron Ciechanover, Avram Hershko, Irwin Rose... 

Ubiquitin is a small but highly conserved protein found exclusively in eukaryotes. The characteristics of this protein were established in the early 1980s. For this monumental work, Aaron Ciechanover, Avram Hersko, and Irwin Rose shared the Nobel Prize in Chemistry in 2004. 

The ubiquitin-mediated degradation of intracellular proteins is a universal phenomenon in eukaryotic cells that is fundamental to the regulation of various cell processes. In 2004, Aaron Ciechanover, Avram Hershko, and Irwin Rose shared the Nobel Prize in chemistry for their discovery of this pathway. 

Aaron Ciechanover (Israel), Avram Hershko (Israel), and Irwin Rose (United States) for the discovery of ubiquitin-mediated protein degradation. While the overwhelming majority of biochemical research on proteins has focused on how they are synthesized and how they function, these three researchers took a unique path and studied how cells regulate their breakdown. They discovered that proteins are broken down (and rebuilt) at a much faster rate than anyone probably would have expected. Proteins are labeled when it is time for them to be broken down, and then they are chopped up into small pieces so that they no longer function. 

Aaron Ciechanover, Avram Hershko, Irwin Rose 1946 James B. Sumner, John H. Northrop, Wendell M. Stanley... 

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