Hershko, Avram

Aaron Ciechanover, Avram Hershko, Irwin Rose... 

How SCNT-hES cells can be applied for myocardial regeneration and transplanta tion is impressively demonstrated by Pro fessor Lior Gepstein from Technion Insti tute in Haifa, Israel. His recent break through achievements were another hallmark in stem cell research and were highlighted by the international press. In addition to his scientific results, the Technion Institute was recently in the scientific spotlight when his colleagues Aaron Chie-chanover and Avram Hershko were awarded the Nobel Prize in 2004. As first... 

The ubiquitin-mediated degradation of intracellular proteins is a universal phenomenon in eukaryotic cells that is fundamental to the regulation of various cell processes. In 2004, Aaron Ciechanover, Avram Hershko, and Irwin Rose shared the Nobel Prize in chemistry for their discovery of this pathway. 

Aaron Ciechanover (Israel), Avram Hershko (Israel), and Irwin Rose (United States) for the discovery of ubiquitin-mediated protein degradation. While the overwhelming majority of biochemical research on proteins has focused on how they are synthesized and how they function, these three researchers took a unique path and studied how cells regulate their breakdown. They discovered that proteins are broken down (and rebuilt) at a much faster rate than anyone probably would have expected. Proteins are labeled when it is time for them to be broken down, and then they are chopped up into small pieces so that they no longer function. 

Aaron Ciechanover, Avram Hershko, Irwin Rose 1946 James B. Sumner, John H. Northrop, Wendell M. Stanley... 

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