Olanzapine typical antipsychotics compared with

In a study of 7139 antipsychotic drug-naive patients with schizophrenia in Denmark who were followed for 6.6 years (47297 patient-years), 307 developed diabetes (annual incidence rate 0.65%) [26 ]. Significant factors associated with diabetes within 3 months of its development included treatment with low-potency typical antipsychotic drugs (OR=1.5 95% CI=1.1, 2.0), olanzapine (OR=1.4 95% Cl=1.0,1.9), and clozapine (OR=1.7 95% Cl=1.1, 2.5), whereas aripiprazole was associated with a lower risk (OR = 0.51 95% Cl=0.33, 0.80). Patients who stopped taking olanzapine or midpotency typical antipsychotic drugs had no increased risk of diabetes compared with patients who took no antipsychotic drugs at any time. 

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