Turnover of Glutamate

Jabaudon D, Shimamoto K, Yasuda-Kamatani Y, Scanziani M, GahwEer BH, et al. 1999. Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc Natl Acad Sci U S A 96(15) 8733-8738. 

A Postsynaptic Dopamine Receptor Regulating the Release or Turnover of Glutamate ... 

Davis M, Myers KM (2002) The role of glutamate and gamma-aminobutyric acid in fear extinction clinical implications for exposme therapy. Biol Psychiatry 52 998-1007 Davis M, Whalen PJ (2001) The amygdala vigilance and emotion. Mol Psychiatry 6 13-34 Davis M, Hitchcock JM, Bowers MB, Berridge CW, Meha KR, Roth RH (1994) Stress-induced activation of prefrontal cortex dopamine turnover blockade by lesions of the amygdala. Brain Res 664 207-210... 

Dopamine induces biochemical and physiological effects in the mammalian neostriatum. The occurrence of a D-l dopamine receptor (in the classification scheme of Kebabian and Caine) accounts for the ability of dopamine to enhance cyclic AMP formation. The occurrence of a D-2 dopamine receptor accounts for the ability of dopamine to inhibit cyclic AMP formation brought about by stimulation of a D-l dopamine receptor. Dopamine receptors mediate the regulation of (1) the release or turnover of acetylcholine (postsynaptic dopamine receptor) and (2) the release or turnover of dopar mine (presynaptic autoreceptor). Both receptors can be classified as D-2 dopamine receptors. Indications for the occurrence of dopamine receptors affecting the release or turnover of GABA, glutamate, serotonin and several neuropeptides are evaluated. 

Huh K-H, Wenthold RJ. 1999. Turnover analysis of glutamate receptors identifies a rapidly degraded pool of the N-methyl-D-aspartate receptor subunit, NRl, in cultured cerebellar granule cells. J. Biol. Chem. 274 151-57... 

Activity Dependant Turnover and Trafficking of Glutamate Receptors in Neurons... 

Stanton, P.K., Chattarji, S. and Sejnowski, T.J. (1991). 2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus. Neurosci. Lett. 127 61-66. 

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