Tumours properties

Sulphide and sulphoxide complexes have been extensively studied since cis-RuC12(DMSO)4 (DMSO, dimethyl sulphoxide, (Me)2SO) was found to have anti-tumour properties and to be a precessor for radiosensitizing agents. Such complexes can act as catalysts for the oxidation of sulphides with molecular oxygen. 

The anti-tumour properties of cryptopleurine (33) continue to stimulate synthetic work in this area, and two new syntheses have been reported this year. Snieckus and co-workers25 have described a short, efficient synthesis of the alkaloid, utilizing a benzamide-directed metallation reaction (Scheme 6). In the other synthesis,26 the piperidine derivative (35), prepared by a nitrone cycloaddition reaction, is cyclized... 

Antiviral, immunoregulatory and anti-tumour properties. Originally called macrophage-activating factor. Especially important in the maintenance of chronic inflammation. 

Methods for isolation of perloline from this species (tall fescue) have been refined. Perloline appears not to exhibit antibiotic activity but shows marginal anti-tumour properties. A fluorometric analytical method for this alkaloid has been developed. ... 

From Ochrosia maculata (O. borbonica), (Apocyn.), 9-methoxyellipticine (56) was isolated " as the substance responsible for the anti-tumour properties of Ochrosia extracts. (56) is active against L-1210 leukaemia in mice resistant to... 

Spectrum of activity. Following the initial report of the anti-tumour properties of a complex containing 1,2-diaminocyclohexane [66], a number of DACH compounds have been synthesized and tested. Unless otherwise noted, all of the complexes described contain the racemic form of the so-called trans isomer, i.e., equal molar amounts of the R,R and S,S optical isomers (Figure 4.1). 

Thioxanthenes and Thioxanthones. - Several possible metabolites of the neuroleptic chlorprothixene (241) have been synthesized for example, the geometric isomers of 3-, 4-, 6-, and 7-hydroxy- and -methoxy-derivatives. Lucanthrone (242 = H) is known to have anti-tumour properties,... 

Substituted 2-iminochromenes (130), which have anti-tumour properties, have been synthesized from the salicylaldehydes (129) and N-substituted cyano-acetamides. ... 

Aminotriol derivative 330 was prepared from the D-lxyose-derived 329. Amide formation and detritylation allowed for glycosylation with the tetra-O-benzyl-a-D-glucosyl bromide, final hydrogenation then giving 331, which has immunosuppressant and anti-tumour properties (Scheme 30). °... 

An even larger cavity exists in K2gLi5H7PgW430i84 92H2O. In this crystalline salt, several K+ lie in channels inside the anion while the remainder, together with Li+ and H+, lie on the outside (Figure 5.49b). The salt has an ion exchange capacity and remains stable at pH 1-8. Large cavity anions such as these are of interest in connection with their anti-viral and anti-tumour properties [96],... 

Similarly, high toxicity mihtates against any useful therapeutic application of the anti-tumour properties [45, 487] of the unusually constituted sesquiter-penoid, illudin S (LXV) [47] (syn. lampterol [46]), just as the marked activity against Staphylococcus aureus [488] displayed by marasmic acid (LXVI) [489,... 

Composition of HA with RNA - interferon inducer (0.15% RNA and 1% HA) is the greatest interferon activator in the animals. The mechanism of action is likely related to the fact that the polysaccharide macromolecule blocks some molecular inflanunatory factors such as CD44 and RNAMM [93,94], has some anti-tumour properties [81] and activates the metabolism and proliferation of normal cells. It is also a possible direct effect of biopolymer on the synthesis of interferon by lymphocytes and monocytes through activation of CD44 in these cells [91]. 

There has been considerable activity in this field since the last review (777) which has no doubt been stimulated by reports of the anti-tumour activity of many of these compounds 255,. 292, 294), although the mechanism of action is not known 330). The anti-tumour properties of some chemically modified lichen polysaccharides have also been studied (257). 

Anti-tumour Properties of NHC-Gold(I) and NHC-Gold(III) Complexes... 

However, metal compounds do play a vital role in modem medicine. One of the most important breakthroughs was the discovery of the anti-tumour properties of platinum complexes, notably cis-platin (Stmcture 3.1), by Barnett Rosenberg and his colleagues in the 1960s. Platinum dmgs are now widely used in cancer chemotherapy, with particular success in the treatment of testicular and ovarian tumours. Other examples include sodium bicarbonate and magnesium and... 

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