Anti-tumour properties complexes

Sulphide and sulphoxide complexes have been extensively studied since cis-RuC12(DMSO)4 (DMSO, dimethyl sulphoxide, (Me)2SO) was found to have anti-tumour properties and to be a precessor for radiosensitizing agents. Such complexes can act as catalysts for the oxidation of sulphides with molecular oxygen. 

Spectrum of activity. Following the initial report of the anti-tumour properties of a complex containing 1,2-diaminocyclohexane [66], a number of DACH compounds have been synthesized and tested. Unless otherwise noted, all of the complexes described contain the racemic form of the so-called trans isomer, i.e., equal molar amounts of the R,R and S,S optical isomers (Figure 4.1). 

Anti-tumour Properties of NHC-Gold(I) and NHC-Gold(III) Complexes... 

However, metal compounds do play a vital role in modem medicine. One of the most important breakthroughs was the discovery of the anti-tumour properties of platinum complexes, notably cis-platin (Stmcture 3.1), by Barnett Rosenberg and his colleagues in the 1960s. Platinum dmgs are now widely used in cancer chemotherapy, with particular success in the treatment of testicular and ovarian tumours. Other examples include sodium bicarbonate and magnesium and... 

In this section we outline briefly the spectral and magnetic properties of complexes of the metals of Table 5. These are the properties that enable the stereo-chemical and electronic structures of metal complexes to be determined in solution and, hence in a biological environment. A study of these properties will be necessary to understand the nature of the interaction of the anti-tumour compounds with biological systems. 

The concept of postmodification of the molecule s periphery is thus not only appropriate for the introduction of simple functionalities determining the physical and chemical properties of the molecule (e.g. solubility), but also allows the introduction of complex function-bearing units (e.g. catalytically active units, anti-tumour agents), which could be too sensitive for convergent dendrimer synthesis. 

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