Tumor-targeting antigens

The list of MoAb or fusion proteins used in treatment of every type of cancer is continually growing as research identifies more cancer-associated antigens. MoAb targeting a tumor-specific antigen is used... 

Besides the hormone therapy, the notion of targeted cancer therapy is not so new and can be traced back to the 1940 s [2]. Early approaches included the largely unsuccessful use of antibodies, often conjugated with radioisotopes or toxins, directed against tumor-associated antigens. 

M. (1987). Tumor targeting potential of liposomes encapsulating Ga-67 and antibody to Dalton s lymphoma associated antigen (anti-DLAA), Int. J. Rad. Oncol. Biol. Phys.. 13, 1713-1719. 

Bacillus Calmette-Guerin (BCG) is a viable attenuated strain of Mycobacterium bovis. Nonviable strains of the bacterium also have been shown to augment the immune response. The smallest active compound derived from BCG thus far has been identified as muramyl dipeptide. The T cell is a principal target for BCG. It also appears to stimulate natural killer cells, which in turn can kill malignant cells. It has been suggested that BCG cross-reacts immunologically with tumor cell antigens. 

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