Tumor optic nerve

Infiltration of the optic nerve most often occurs from autoimmime inflammatory processes or tumor. Common infiltrative sources include sarcoidosis, SLE, leukemia, lymphoma, and primary tumors of the optic nerve. 

The primary optic nerve tumor that originates within the optic nerve is glioma. Affected patients often present with reduced visual acuity, visual field defects, transient visual obscurations, and disc edema. 

SLE is most commonly diagnosed by the clinical constellation of signs and antinuclear antibody testing, anti-double-stranded DNA, the Smith and RNP antibodies, and antibodies to RO and LA (SS-A and SS-B). The suspicion of leukemia requires a hematology and oncology workup that includes a complete blood count. Primary tumors of the optic nerve are diagnosed based on appearance, growth, and, occasionally, biopsy. 

Factors that mimic glaucomatous visual field loss include branch retinal artery occlusion chorioretinal scars retinal areas treated by photocoagulafion or cryotherapy demyelin-afing disorders cerebrovascular accidents, tumors, or other lesions affecting the optic nerve, chiasm, optic tract, optic radiation, ancPor the remaining course of nerve fibers to the occipital cortex. Other abnormalities that could account for pseudo-glaucomatous visual field defects or vision loss include vitreous hemorrhage, proliferative retinopathy or other retinal disorders. 

Neurofibroma may occur as a sporadic tumor or as part of the dominantly inherited tumor syndrome called von Recklinghausen disease or neurofibromatosis-1 (NF-l).i Plexiform neurofibromas are multiple swollen fascicles that are associated with NF-1. Other nervous system signs of NF-1 are more than one neurofibroma, optic nerve glioma (more appropriately called optic nerve pilocytic astrocytoma), and malignant peripheral nerve sheath tumor with glandular or rhabdomyoblastic regions. ... 

Yan X, Tezel G, Wax MB, Edward DP. Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch Ophthalmol 2000 118 666-673. 

BMPS (653) 6pl2.1 May act as a signaling molecule in the trabecular meshwork and optic nerve head, and may play a role in the pathogenesis of glaucoma the gene is differentially regulated during the formation of various tumors... 

Meningeoma of the optic nerve sheath complex is a benign, extra-axial tumor entity that is predominantly found in adults, with a mean age of approximately 40... 

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