Tumor necrosis factor polymorphonuclear neutrophils

Cicco, N. A., Lindemann, A., Content, J., Vandenbussche, P., Lubbert, M., Gauss, J., Mertelsmann, R., Herrmann, F. (1990). Inducible production of Interleukin-6 by human polymorphonuclear neutrophils Role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood 75,2049-52. 

Shalaby MR, Aggarwal BB, Rinder-knecht E, Svedersky LP, Finkle BS, Pal-ladino MA Jr. 1985. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. J. Immunol. 135 2069-73... 

In experimentally induced brain focal ischaemia, the upregulation of ICAM-1 and the induction of E- and P-selectm1719 is believed to result from the activity of inflammatory cytokines such as tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6), which are produced by the ischaemic brain20-21 or by the reoxygenation of microvascular endothelial cells.22 There is a direct association between increased expression of ICAM-1 andE-selectin,19-23 the appearance of inflammatory cytokines,20 and the degree of polymorphonuclear (PMN) cell infiltration into ischaemic tissue. Moreover, cultured murine brain microvascular endothelial cells stimulated with IL-1 () or TNF-a express E-selectin and ICAM-1 and support neutrophil adhesion.24... 

Abbreviations used in this chapter AZT, 3 -azidothymidine CD, cluster of differentiation CHS, Chediak-Higashi syndrome Con A, concanavalin-A EAE, experimental allergic encephalomyelitis HIV, human immunodeficiency virus HTLV-1, human T-cell leukemia virus-1 IL, interleukin INF, interferon NAC, N-acetyl cysteine NF-kB, neurotrophic factor-k beta PBMC, peripheral blood mononuclear cells PM A, phorbol 12-myristate 13-acetate PMN, polymorphonuclear neutrophil RT, reverse transcriptase TNF-2 tumor necrosis factor alpha. 

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