Tumor host resistance models

Host resistance studies, usually using murine challenge with pathogens such as influenza virus, CMV, Listeria, streptococcus, or tumor host resistance models with subcutaneous (sc), injection of tumor cell lines. 

Neutrophil function (phagocytosis and bactericidal activity) Host resistance models Response to challenge with infectious agent or tumor cells... 

Tier 2 also include host resistance models, tests in which an animal is exposed to a xenobiotic and then challenged with an infectious agent or tumor cells. This is considered the ultimate test for an adverse effect on the immune system. However, it should be noted that the amount of immune suppression that can be tolerated is greatly dependent on the dose and virulence of the challenging agent, as well as the genetics of the host. Manipulation of these variables can affect greatly results obtained in host resistance tests. 

Host resistance Bacterial models—Listeria monocytogenes (mortality or spleen clearance) Streptococcus species (mortality) Viral models—influenza (mortality) Parasitic models—Plasmodium yoelii (parasitemia) or Trichinella spiralis (muscle larvae counts and worm expulsion) Syngeneic tumor models—PYB6 sarcoma (tumor incidence) B16F10 melanoma (lung burden). 

---