Trophozoite extract

Slater and Cerami reported the trophozoite extracts of P. falciparum could polymerize monomeric heme in a protein concentration-, time- and pH- dependent fashion. Further, this activity, attributed to a heme... 

In related work, Martiney et al. showed that metalloporphyrins with zinc or tin were capable of inhibiting hemozoin formation in trophozoite extracts [105]. Zn(II) and Sn(IV) analogs of heme were selected for study as a result of their known competitive interactions with heme in a number of systems and their use as pharmacological photosensitizers. The order of efficacy for these metalloporphyrins was ZnDPIX>SnPPIX ZnPPIX. This order is consistent with the proposed... 

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