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Troglitazone

Troglitazone is useful in insulin resistance. This drug was withdrawn because of hepatotoxicity, but many derivatives have been prepared and are at various stages of clinical trials. Perhaps this will be a future drug for the treatment of diabetes. Patients who take antidiabetic drugs should be frequently monitored for blood glucose levels. Shorter intervals of food intake in small quantities are beneficial for known diabetic patients to avoid sudden hypoglycemia. [Pg.284]

Pfizer introduced troglitazone in 1997 and marketed it as Rezulin, an oral treatment for type 2 diabetes. Warner Lambert Co., which was acquired by Pfizer in June 2000, discontinued marketing this drug in March 2000. In January 2003, the company [Pg.10]

Its use was associated with a markedly increased risk of acute idiopathic liver injury and acute liver failure [50]. [Pg.11]

Especially cardiovascular toxicity and hepatotoxicity played a crucial role in the decisions for withdrawing drugs from the market. These data suggest that there are [Pg.11]

Hepatotoxicity, addiction and neuropsychotic disorders Cardiovascular (agranulocytosis) Cardiovascular (hERG block) [Pg.11]

Development of hypoglycemic agent troglitazone (CS-045). 6-hydroxy-2-[p-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-2,5,7,8-tetramethylchro-mane 97YZ597. [Pg.234]

C 3H 9Br02 84071-98-7) see Troglitazone 5-(2-bromoethyl)-2,2-dimethyl-]3-dioxane (C, H 5Br02 97845-58-4) see Penciclovir 4-(2-bromoethyl)-l-ethyl-3,3-diphenyl-2-pyrTolidinone (C2oH22BrNO 3192-92-5) see Doxapram... [Pg.2313]

C-iHi]Br02, 55311-87-0) see Troglitazone cc>(bromomethyl)-2-chlorobenzenemethanol (CjjlLBiClO 72702-57-9) see Clorprenaline 3-(broniomethyl)-7-chlorobenzo[Z>]thiophene (CyHftBrClS 17512-61-7) see Sertaconazole... [Pg.2314]

CO2 124-38-9) see p-Aminosalicylic acid Gentisic acid Indecainide Lamotrigine Salicylic acid Troglitazone L-Tryptophan carbon disulfide... [Pg.2321]

C25H27CIO3 /O/Oy-i -J) see Trenbolone acetate ( )-2-chioro-3-[4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)incthoxy]phenyl]propionic acid (C23H27C10 97322-69-5) sec Troglitazone 4 -chloro-2 (24midazoUn-2-yl)benzophenone (Ci HjiClNjO 22590-J7-6) see Mazindo ... [Pg.2330]

C1H5CIO 107-30-2) see Cefoxitin Troglitazone 3 (chloromethyl) l melhylplperidine methyMA5,6-tetrahydropyrimidine (QHi,CIN2) see Oxyphencyclimine... [Pg.2331]

CUH22O4 233757-09-0) see Troglitazone (+)-3,4-dihydro-4-hydroxy-2ff-thieno[3,2-e]-l,2-thiazine... [Pg.2355]

C5Hj 02 140-88-5) see Acrivastine Azelastine Benperidol Benzquinamide Setiptiline Troglitazone ethyl adipoyl chloride... [Pg.2375]

C20H27NO4 58115-88-1) see Butorphanol hexahy dro-1 -methyMH-azepin-4-one (C7H13NO 1859-33-2) see Azelastine (3S-trflns)-hexahydro-2-phenyl-l /-pyrroloLl,2-c]imid-azoIe-3-carboxylic acid methyl ester (C14H1KN2O2) see Troglitazone hexahydro-l-(2-propenyl)<4i/-azepin-4-one (CyHi NO) see Talipcxole... [Pg.2392]

CHjlMg 917-64-6) see Calcifediol Dexamethasone Fenpentadiol Indalpine Mesterolone Methyltestosterone Nabilone Paramethasone Tiaprofenic acid Troglitazone methyl malonamate (C4H7NO, 51513-29-2) see Cefotetan methyl malonate lithium salt (C4H,Li04 63460-24-2) see Misoprostol methyl mercaptane... [Pg.2417]

C13H20N2O4 133228-95-2) see Talinolol 4-(p-nitrophenoxy)-3-methyl-2-buten-l-ol (C11H13NO4 171180-10-2) see Troglitazone 4-(p-nitrophenoxy)-3-methyl-2-butenyl acetate (C13H15NO5 171180-09-9) see Troglitazone... [Pg.2427]

See other pages where Troglitazone is mentioned: [Pg.2125]    [Pg.2125]    [Pg.2126]    [Pg.2127]    [Pg.2128]    [Pg.2128]    [Pg.2129]    [Pg.2279]    [Pg.2280]    [Pg.2280]    [Pg.2282]    [Pg.2282]    [Pg.2307]    [Pg.2307]    [Pg.2313]    [Pg.2316]    [Pg.2352]    [Pg.2355]    [Pg.2355]    [Pg.2355]    [Pg.2356]    [Pg.2360]    [Pg.2360]    [Pg.2375]    [Pg.2381]    [Pg.2394]    [Pg.2395]    [Pg.2397]    [Pg.2401]    [Pg.2401]    [Pg.2403]    [Pg.2408]    [Pg.2413]    [Pg.2424]    [Pg.2424]    [Pg.2427]    [Pg.2427]    [Pg.2427]    [Pg.2436]    [Pg.2446]   
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Cytotoxicity, troglitazone-induced

Diabetes troglitazone

Peroxisome proliferator-activated receptor troglitazone

Rezulin - Troglitazone

Simvastatin Troglitazone

Troglitazone hepatotoxicity

Troglitazone structure

Troglitazone-induced hepatotoxicity

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