Troglitazone hepatotoxicity

Masubuchi, Y. (2006) Metabolic and non-metabolic factors determining troglitazone hepatotoxicity a review. Drug Metabolism and Pharmacokinetics, 21 (5), 347-356. 

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Jaeschke, H. Troglitazone hepatotoxicity Are we getting closer to understanding idiosyncratic liver injury Toxicol. Sci. 2007, 97, 1-3. 

Nozawa T, Sugiura S, Nakajima M, et al. Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos 2004 32(3) 291-294. 

Hypersensitivity Reaction Associated with Troglitazone Hepatotoxicity.426... 

Keywords Troglitazone Hepatotoxicity Active metabolites CYP3A Hypersensitivity... 

Troglitazone represents a model of an idiosyncratic drug reaction that led to withdrawal from the market and to attempts to understand the mechanisms of such adverse drug reactions. This review summarizes the proposed molecular mechanisms of troglitazone hepatotoxicity based on both in vivo and in vitro studies. However, so far, there is no direct evidence indicating the precise mechanism of the toxicity. Many factors have been proposed to contribute to this idiosyncratic toxicity. 

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