Triterpenes glycyrrhizin

Licorice root For the triterpene glycyrrhizin (extracted from the licorice root Glycyr-rhiza radix) the mode of anti-HIV action may be attributed at least in part to interference with virus-cell binding. 

Glycyrrhizin (triterpene saponin) Glycyrrhiza glabra (Fabaceae) Thrombin interactions (but not catalytic activity) [109]... 

Several naturally occurring triterpenes have been reported to show anti-HIV activity, e.g. betulinic acid, platanic acid, glycyrrhizin, mimusopic acid, gano-deriol and geumonoid.16 20 These active compounds hold the potential to serve as hits or leads for anti-HIV drug development.21,22 The focus of this chapter is bevirimat, the first in a new class of compounds termed HIV maturation inhibitors (Mis). Our discussion covers modification, structure-activity relationship (SAR), mechanism of action studies and clinical trials of bevirimat. 

Glycyrrhinic acid Glycyrrhizin Glycyrrhizinic acid) (triterpene saponin) Fabaceae) [rhizome, root] CBG, CORT-R, EST-R, 11 (3HSDH, SBG) [anti-ulcerogenic, expectorant, sweet]... 

Glycyrrhizinic acid) (triterpene glycoside saponin) expectorant, sweet]... 

Glycyrrhizin, 18a-glycyrrhetinic acid, 18/3-glycyrrhetinic Triterpene saponins Glycyrrhiza glabra Analytical RPC UV 254nm 97... 

Seki H, Sawai S, Ohyama K, Mizutani M, Olmishi T, Sudo H, Fukushima EO, Akashi T, Aoki T, Saito K, Muranaka T (2011) Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin. Plant Cell 23 4112 123... 

Glycyrrhizin has been found to concentrate in the woody parts of the thickened root and stolon of G. glabra. Betulinic acid and soya-saponins have been previously reported from G. glabra cell cultures. Recently, soyasapo-nins (oleanane-type triterpene glycosides) have been reported in all parts of the intact plant, especially the seeds and young roots, particularly rootlets. ... 

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