Platanic acid

Fujioka T, Kashiwada Y, Kilkuskie RE, Cosentino EM, Balias LM, Jiang JB, Janzen WP, Chen IS, Lee K-H. (1994) Anti-AIDS agents, 11. betulinic acid and platanic acid as anti-HIV principles from syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 57 243-247. 

Betulinic acid and platanic acid are triterpenoids isolated from Syzygium claviflorum. They exhibit inhibitory activity against HIV-1 replication in H9 lymphocyte cells at an IC50 of 1.4 and 6.5 pM, respectively (selectivity index 9.3 and 14, respectively). Hydrogenation of betulinic acid... 

Several naturally occurring triterpenes have been reported to show anti-HIV activity, e.g. betulinic acid, platanic acid, glycyrrhizin, mimusopic acid, gano-deriol and geumonoid.16 20 These active compounds hold the potential to serve as hits or leads for anti-HIV drug development.21,22 The focus of this chapter is bevirimat, the first in a new class of compounds termed HIV maturation inhibitors (Mis). Our discussion covers modification, structure-activity relationship (SAR), mechanism of action studies and clinical trials of bevirimat. 

Platanic acid (triterpene) Melaleuca leucadendron, Syzygium claviflorum (Myrtaceae) PKC [anti-HIV]... 

Two lupane triterpenes, bemhnic acid (Ml) and platanic acid (M2), from Syzigium claviflorum Wall. (Myrtaceae family) were reported first to reduce HIV IHB reproduction by 50% in H9 lymphocytes (118). Afterwards, many derivatives were... 

Fujioka, T. Kashiwada, Y. Kilkuskie, R.E. Cosentino, L.M. Balias, L.M. Jiang, J.B. Janzen, W.P. Chen, I.S. Lee, K.-H. Anti-AIDS Agenta, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigum claviflorum and The Anti-HIV Activity of Structurally Related Triterpenoids. J. Nat. Prod. 1994, 57, 243-247. 

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