Tripterygium wilfordii Triptolide

Tripterygium wilfordii Hook. f. Lei Gong Teng (Yellow vine) (root) Tripchilorolide, celastrol, triptein, wilfordine, triptophenolide, triptonide, triptolide, tripdiolide, triptolidenol, tripchlorolide, triptolide, tripdioltonide, trihydroxytriptolide, triptolide.33-241-390-431-443 This herb is toxic with adverse effects on gastrointestinal tract. Antifertility effect on male, anti-inflammatory, antitumor, treat cancer, antirheumatoid arthritis, suppressive effects. 

Di33 Triptolide Tripterygium wilfordii APO, COX, NFkB, TNFa [96,196-200]... 

TongLuoJiuNao (Geniposide and Ginsenoside Rgl) Tripterygium wilfordii Hook F Triptolide Turmeric... 

Triptolide, isolated from the herb Tripterygium wilfordii Hook F, has anti-inflammatory and immunosuppressive activities, and... 

S. M. Kupchan, W. A. Court, R. G. Dailey, C. J. Gilmore, R. F. Bryan, Tumor mhibitors. LXXiV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii, J. Am. Chem. Soc. 94 (1972) 7194. 

The unusual triepoxide triptolide (33) was first isolated from Tripterygium wilfordii Hook F. or the thunder god vine by the late Morris Kupchan as part of his systematic investigation of natural products as potential anticancer agents. T. iDilfordii is used in traditional Chinese medicine for the treatment of arthritis and related... 

Triptolide from Tripterygium wilfordii was also shown to exhibit antitumoral and anti-inflammatory effects by inhibiting cell proliferation, inducing apoptosis, and inhibiting both NF-kB and AP-1 transcriptional activity. However, since this compound neither inhibited growth nor induced apoptosis in cells with mutant p53, it clearly requires a functional p53 to exhibit any proapoptotic, anti-inflammatory, or antitumoral effect. [172]. 

Triptolide (103) and tripdiolide (104) from the celastra-ceous plant, Tripterygium wilfordii, exhibit antituriior activity in the L-1210 (lymphoid leukemia), P-388, and KB test systems (Cordell, 1978). 

Cheng ZZ, Yang XQ, Wang LQ, Lu P 1984 Quantitative determination of Triptolide in common three-wing-nut Tripterygium wilfordii). Chung Ts Ao Yao 15 339-340... 

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