Tripterygium wilfordii triptolide from

Triptolide from Tripterygium wilfordii was also shown to exhibit antitumoral and anti-inflammatory effects by inhibiting cell proliferation, inducing apoptosis, and inhibiting both NF-kB and AP-1 transcriptional activity. However, since this compound neither inhibited growth nor induced apoptosis in cells with mutant p53, it clearly requires a functional p53 to exhibit any proapoptotic, anti-inflammatory, or antitumoral effect. [172]. 

S. M. Kupchan, W. A. Court, R. G. Dailey, C. J. Gilmore, R. F. Bryan, Tumor mhibitors. LXXiV. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii, J. Am. Chem. Soc. 94 (1972) 7194. 

The unusual triepoxide triptolide (33) was first isolated from Tripterygium wilfordii Hook F. or the thunder god vine by the late Morris Kupchan as part of his systematic investigation of natural products as potential anticancer agents. T. iDilfordii is used in traditional Chinese medicine for the treatment of arthritis and related... 

Triptolide, isolated from the herb Tripterygium wilfordii Hook F, has anti-inflammatory and immunosuppressive activities, and... 

Triptolide (103) and tripdiolide (104) from the celastra-ceous plant, Tripterygium wilfordii, exhibit antituriior activity in the L-1210 (lymphoid leukemia), P-388, and KB test systems (Cordell, 1978). 

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