DNA triple helix

Nucleic acid structures and sequences primary and secondary structure of DNA fragments, translocation of genes between two chromosomes, detection of nucleic acid hybridization, formation of hairpin structures (see Box 9.4), interaction with drugs, DNA triple helix, DNA-protein interaction, automated DNA sequencing, etc. 

A novel approach to specific binding involves the use of triple-helix affinity capture [26,27]. Triple-helix DNA has proven to be a useful approach to... 

Some research over a number of years has been devoted to the existence of triple helix DNA, which results from the interaction of native and single stranded DNA [9-11]. The triple helix complex formed between two strands of poly(uridylic acid) and one strand of poly(adenylic acid) was first described in 1957 by Felsenfeld [4]. Later in 1959, Hoogsteen [12]... 

These interesting observations could be explained through the formation of triple helix DNA on the electrode surface. Side- and main-chain atoms may interact with a particular DNA base-pair of another chain or with more than one base-pair supporting each other in interwoven hydrogenbonding networks that stabilize the contacts between the bases, forming a triple helix on the DNA adsorbed to the electrode surface [9-11]. The triple helix DNA is formed by interaction of the ssDNA in the bulk... 

DNA supercoiling provides conformational potential energy for DNA tertiary structure formation such as the development of DNA cruciform structures (Figure 1.77). Supercoiling also leads to the creation of DNA triple helix (DNA triplex) structures, which form when an oligodeoxynucleotide chain, with an appropriately complementary deoxynucleotide residue... 

Regulation of mRNA transcription and DNA bending by using triple helix forming oligonucleotide 99YGK194. 

Moser H.E., Dervan P.B. Sequence-specific cleavage of double helical DNA by triple helix formation. Science 1987 238 645-650. 

The head-to-tail-coupling reactions described above are potentially useful in the design of dynamic combinatorial libraries. Features of these reactions include the rapid and reversible formation of carbon-carbon bonds, multifunctional ene-imine building blocks, and formation of stereo centers upon ene-imine linkage. Support for template-directed synthesis utilizing ene-imine building blocks is the formation of a poly ene-imine species that could recognize 3 -GGA-5 sequences of DNA.48 It is noteworthy that some polyene-imines are helical and could form a triple helix with DNA. 

Escude C, Sun J-S (2005) DNA Major Groove Binders Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands and Cleaving Agents. 253 109-148 Evans SV, see Schuman B (2007) 272 217-258 Van der Eycken E, see Appukkuttan P (2006) 266 1-47... 

Neves C, Byk G, Scherman D, Wils P. Coupling of a targeting peptide to plasmid DNA by covalent triple helix formation. FEBS Lett 1999 453 41-45. 

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