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3,16,20-Trihydroxy-5-pregnene

Preparation of 9a-Bromo-110,17a 1 Trihydroxy-16 -Methyl-4-Pregnene-3,20-Dione 21-Acetate To a mixture of 620 mg of 17a,21-dihydroxy-16/3-methyl-4,9(11 )-pregnadiene-3,20-dione 21-acetate and 330 mg of N-bromosuccinimide in 10 ml of dioxane and 3.2 ml of water cooled to 10°C was added 1.8 ml of cold 1 M aqueous perchloric acid. The mixture was stirred at 15°C for 3 hours. Excess N-bromosuccinimide was destroyed by addition... [Pg.165]

Preparation of 9a-Fluoro-110,17a,21-Trihydroxy-160-Methyl-4-Pregnene-3,2O-Dione 21-Acetate To a solution of 200 mg of 9(3,11(3-epoxy-1 7a,21-dihydroxy-16(3-methyl-4-pregnene 3,20-dione 21-acetate in 2 ml of chloroform and 2 ml of tetrahydrofuran in a polyethylene bottle at -60°C was added 2 ml of a 2 1 (by weight) mixture of anhydrous hydrogen fluoride and tetrahydrofuran. After 4 hours at -10°C the mixture was cooled to -60°C and cautiously added to a stirred mixture of 30 ml or 25% aqueous potassium carbonate and 25 ml of chloroform kept at -5°C. The aqueous phase was further extracted with chloroform and the latter phase washed with water and dried over magnesium sulfate. The residue on crystallization from acetone-ether gave pure 9a-fluoro-11(3,17a,21-trihydroxy-16(3-methyl-4-pregnene-3,20-dione 21-acetate. [Pg.166]

Preparation of 9a-F uoro-11, 17a,21 -Trihydroxy-16 Methy -1,4-Pregnadiene-3,20-Dione 21-Acetate 100 mg of 9a-f uoro-11(3,17a,21-trihydroxy-16(3-methyl-4-pregnene-3,20-dione 21-acetate was treated with selenium dioxide to produce the corresponding 9a-fluoro-11(3, 17a,21-trihydroxy-16(3-methyl-1,4-pregnadiene-3,20-dione 21-acetate. Alternately, Bacillus sphaericus may be utilized. [Pg.166]

A solution of 0.144 g of the 3-ethy ene glycol ketal of 5Q ,1 1/3,17Q ,21-tetrahydroxy-6/3-fluoro-16Q -methylallopregnane-3,20-dione 21-acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an ice-salt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°Cand -15°C. The solution wasthen diiuted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at BO t or less to give 60 -fluoro-11/3, 170 ,21 -trihydroxy-16Q -methyl-4-pregnene-3,20-dione 21-acetate. [Pg.1163]

D-spirost-4-ene-3-one 1,4-androstadiene-3,16-dione, 20a-hydroxy-4-pregnene-3,16-dione 3a, 11 p,20a-trihydroxy-5a-pregnane-16-one Fusarium solani Vertidllium theobromae Stachylidium bicolor... [Pg.300]

The hormone cortisol is lip, 17a, 21-trihydroxy-4-pregnene-3,20 dione. It is the major glucocorticoid synthesised and secreted by the human adrenal cortex. Cortisol enters the cell then binds to its receptor. The cortisol-receptor complex enters the nucleus and binds to DNA. [Pg.260]

Preparation of 9p,lip-Epoxy-17a-21-Dihydroxy-16p-Methyl-4-Pregnene-3,20-Dione 21-Acetate To a stirred solution of 100 mg of the 9a-bromo-lip,17a,21-trihydroxy-16p-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of... [Pg.605]

Names synonyms FLUOROHYDROCORTISONE fludrocortisone 9a-fluorohydrocortisone 9a-fluorocoriisol fluohydrisone 9a-fluoro-11 17a.21 -trihydroxy-4-pregnene- 3.20-d lone 9a-fluoro-17-hydroxycorticosterone. FLUOROMETHOLONE 9a-fluoro-l ip,l7a-dihydroxy-6a-methyl-1.4-prcgnadiene 3,20-dione 21 -desoxy-9a-fluoro-6 -methyl-prednisolone. FLUPREDNISOLONE 6a- fluoroprednisolone 6a-fluoro-1 -dehydrohydrocortisone 6a-fluoro-11 17a.21 -trihydroxy-1,4-pregnadienc-3.20-dione. [Pg.2632]

Names synonyms FLURANDRENOLONE 6 fluoro i 6s hyd roxyhyd rocori isone 16.17-acelonidc 6a-fluoro 11, 21 -dehydroxy-16s. 17 s-isopropylidenedioxy-pregna-4-ene 3, 20-dione. HYDROCORTISONE cortisol 17-hydroxycorticosterone hydrocortisone free alcohol l 0, 7s.21 trihydroxy-4-pregnene-3.20-dione 4-pregnene-11 17a, 21 lriol-3.20-dione Kendall compound F Reichstein substance M. HYDROCORTISONE ACETATE cortisol acetate hydrocort isone-21 -acetate 17-hydroxycorticosterone-21 -acetate. [Pg.2633]

Preparation of 9fi,110- poxy-17oi-21-Dihydroxy-16p-Methyl-4-Pregnene-3 O-Dione 21-Acetate To a stirred solution of 100 mg of the 9a-bromo-11)3,17a,21-trihydroxy-16 3-methyl-4-pregnene-3,20-dione 21-acetate in 3 ml of tetrahydrofuran and 1 ml of methanol under nitrogen was added 1.02 ml of 0.215 N methanolic sodium methoxide. After 10 minutes at 25°C, 0.2 ml of acetic acid was added and the methanol removed in vacuo. The residue was acetylated with 1.00 ml of pyridine and 0.5 ml of acetic anhydride at 60°C for 70 minutes. The mixture was taken to dryness in vacuo, water added, and the product extracted into chloroform. The residue was crystallized from ether-acetone to give pure 9/3,11 )3-epoxy-17a,21 -dihydroxy-16/3-methyl-4-pregnene-3,20-dione 21 -acetate. [Pg.166]

Preparation of 9a-Bromo-110,17a 1-Trihydroxy-16l3-Methyl-4-Pregnene-3,2O-Dione 21-Acetate To a mixture of 620 mg of 17a,21-dihydroxy-16/3-methyl-4,9(11)-pregnadiene-... [Pg.165]

Preparation of 9a-Fiuoro-1ip,17a,21-Trihydroxy-16P-Methyi-4-Pregnene-3 0-Dione 21-Acetate To a solution of 200 mg of 9/3,11 3-epoxv-17o ,21-dihydroxy-16/3-methvl-4-pregnene... [Pg.166]

See other pages where 3,16,20-Trihydroxy-5-pregnene is mentioned: [Pg.653]    [Pg.383]    [Pg.166]    [Pg.686]    [Pg.723]    [Pg.742]    [Pg.743]    [Pg.760]    [Pg.760]    [Pg.774]    [Pg.775]    [Pg.779]    [Pg.969]    [Pg.1022]    [Pg.1685]    [Pg.1022]    [Pg.388]    [Pg.1922]    [Pg.509]    [Pg.312]    [Pg.648]    [Pg.724]    [Pg.2633]    [Pg.2789]    [Pg.166]    [Pg.686]    [Pg.166]   


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