Pregnen

Oxime 26 was prepared from 5,ll-dihydro-dibenzo[a,d]cyclohepten-10-one. The Hoch-Campbell reaction of 26 with 3-dimethylaminopropylmagnesium bromide produced aziridine 27 in 46% yield after acidic workup. Extension of the Hoch-Campbell reaction to steroids has also been reported. Thus, treatment of 3(3-hydroxy-5-pregnen-20-one oxime (28) with methylmagnesium iodide furnished a mixture of diastereomers, 20ot/20P,21-imino-20-methyl-5-pregnen-3P-ol (29) in a 50% combined yield and a 3 1 ratio. On the other hand, homo-adamantan-4-one oxime (30) was transformed to homo-adamantano[4,5-b]-2 -ethylaziridine (31) in 76% yield upon the action of... [Pg.24]

Acetoxy-18-hydroxy-18,20/3-oxido-5-pregnene, oxidation to 18,20-lac-tone, 46, 57... [Pg.119]

Chromium trioxide, in oxidation of 18-iodo- and 18-hydroxy-18,2O0-oxido-5-pregnene to 18,20-lactone, 46, 59... [Pg.124]

Hydroxyglutakonitrile, 46, 48 H> droxylamine O sulfonic acid, addi tion to cyclohexanone, 46, 83 18 Hydroxy 18,20/1 oxido-5 pregnene, 46,56... [Pg.131]

Iodine in functionalization of C 19 meth> 1 group of 3d acetoxy 20/3 hydroxy 5 pregnene 46, 58 Iron powder in preparation of ketones from carboxylic acids, 47, 75 Isobutene, 45, 49... [Pg.131]

Lead tetraacetate, assay for, 46, 63 in functionalization of C-19 methyl group of 3/3 acetoxj -200-hydroxy-5 pregnene, 46, 58... [Pg.132]

Lithium aluminum tn t butoxyhj dride in reduction of 3 acetoxy 5-pregnene 20 one, 46, 58 Lithium amalgam, reaction with 3,4-dichloro 1,2,3,4 tetramethylcy clobutene, 46, 36... [Pg.132]

Red phosphorus in bromination of 7 butj rolactone 46, 22 Reduction, of 3/3 acetoxy 5 pregnene 20-one with lithium aluminum tn t butoxyhydnde, 46, 57 of 4-f butylcyclohexanone with lithium aluminum hydride aluminum chloride, 47,16... [Pg.137]

A number of pregnanes have recently been isolated from marine invertebrates. Pregnenolone (5-pregnen-3/l-ol-20-one) (112) and pregnane diols 113... [Pg.29]

B. 3 -Acetoxy-18-iodo- and 18-hydroxy-18,20 -oxido-5-pregnene. In a 5-1. three-necked flask fitted with a mechanical stirrer, a thermometer, and a reflux condenser are placed 31. of cyclohexane (Note 6), 180 g. ca. 0.37 mole) of commercial lead tetraacetate containing approximately 10% acetic acid (Note 7), 24 g. (0.095 mole) of iodine and 30 g. (0.083 mole) of 3j3-acetoxy-20j8-hydroxy-5-pregnene. The reaction mixture is stirred and heated to the boiling point by irradiation with a 1000-watt lamp (Note 8) from underneath. When the iodine color has disappeared (usually after about 60-90 minutes) (Note 9), the reaction mixture is cooled to room temperature, filtered with suction, and the... [Pg.30]

A, 3 -Acetoxy-20 hydroocy-5-pregnene. In a 2-1. five-necked flask fitted with a mechanical stirrer, 250-ml. dropping funnel,... [Pg.93]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...