Trigonelline fenugreek

Trigonella foenum-graecum L. Wu Ru Ba (Fenugreek) (seed) Trigonelline, saponins, flavone derivatives including vitex, saponaretin, isoorientin, vitexin-7-glucoside.33 Reduce plasma cholesterol levels, support hepatic and renal functions. 

Dry fenugreek contains trigonelline during roasting two-thirds of trigonelline is converted into niacin or nicotinic acid. Nicotinic acid is almost absent in the former. It is reported that fermentation increases both free and total niacin. 

The LD50 of an intraperitoneally administered ethanol extract of fenugreek in rats is 500 mg/kg (Sharma et al. 1978). The LD50 of the compound trigonelline orally administered to rats is 5 g/kg (Mishkinsky et al. 1974). 

Trigonelline (54), first isolated from fenugreek seed Tri-gonella foenum-graecum, Fabaceae), is now known to be widespread in plants (Fodor and Colasanti, 1985). Trigonelline promotes cell arrest in G2 of the cell cycle in plants (Wink, 1993). 

Another nicotinic acid derivative is trigonelline, found in fenugreek seed (Trigonella foecum-graecum) and unroasted coffee beans. 

Trigonelline and fenugreek infusion have been shown to have hypoglycemic effects in animals. However, the effects of trigonelline in diabetics have been inconclusive (martindale). ... 

Trigonelline, or N-methylnicotinic acid, is a secondary metabolite derived from pyridine nucleotides. Trigonelline was first isolated from fenugreek (Trigonellafoenum-graecum)... 

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