Triethyl tin

The toxicity of the tetraorganotins has beenUtde studied. Available Hterature indicates that tetrabutyltin and the higher tetraalkyltins are substantially less toxic than triorganotins to mammals if taken orally (175). The high toxicity reported for tetraethyltin (LD g = 9 16 mg/kg) appears to be caused by its rapid conversion in the Hver to a triethyl tin species. 

A more detailed study (50) of the 119Sn chemical shifts of trimethyl-and triethyl-tin chloride as a function of concentration and temperature in various polar solvents has revealed the effect of complexing on chemical shift. The formation of a 1 1 complex of trialkyltin chloride in a polar donor solvent, L, may be written as ... 

Eto Y, Suzuki K, Suzuki K. 1971. Lipid composition of rat brain myelin in triethyl tin-induced edema. J Lipid Res 12 570-579. 

Smith ME. 1973. Studies on the mechanism of demyelination Triethyl tin-induced demyelination. J Neurochem 21 357-372. 

BIS-2,3,5-TRICHLOR-6-HYDROXYFENYLMETHAN (CZECH) see HCLOOO BIS(3,5,6-TRICHLORO-2-HYDROXYPHENYL)METHANE see HCLOOO L4-BIS-TRICHLOROMETHYL BENZENE see HCM500 BIS(TRIETHYL TIN) SULFATE see BLN500 BIS (TRIFLUOROMETHYLTHIO)MERCURY see BLQ525... 

Plastic pipes are polymeric in nature (e.g., polyvinyl chloride). Within the pipe are traces of the monomers used in the manufacture of the pipe (e.g., vinyl chloride). In addition, there are a variety of other chemicals added during the manufacture of the pipe as lubricants to facilitate their manufacture or stabilizers to prevent the breakdown of the pipe. In Europe, lead has been used as the stabilizer for pipes, whereas various organic tin compounds have been utilized in the United States. Lead is widely recognized as being toxic. Inorganic tin has a very limited toxicity, but this is not the form of tin that is used. Some of the organic tin compounds are potent nervous system toxins (e.g., trimethyl or triethyl tin), while others appear to adversely affect the immune system (dioctyl tin). The forms of tin used in polyvinyl chloride pipe, however, are primarily monomethyl and dimethyl tin, which are much less active as neurotoxins than the trimethyl tin. There will be some extraction of all these chemicals from the pipe when it is first put into service. However, the concentrations that are found in the water decrease sharply with continued use of the pipe. This is only partially due to the depletion of the chemical from the pipe because continuous water flow will form an impermeable barrier (e.g., calcium carbonate) on the interior of the pipe that minimizes leaching from its surface. 

There are no case reports of toxicity in man for monoalkyltin compounds. Diiodo diethyl tin contaminated with 10% triethyl-tin iodide in STALINON capsules (a preparation proposed for the treatment of furuncles) caused 100 fatalities in France between 1953 and 1954. The lesion was an interstitial edema of the white matter of the brain, and the symptoms included headache, vertigo, psychic and visual disturbances, hypothermia, loss of vigilance, paresthesia, vomiting, abdominal pain, urinary retention, tremors, and convulsions. Another 100 patients survived the intoxication, but presented headaches and weakness over a period of several years (Alajouanine etal. 1958)... 

In view of the large differencies in toxicity even within the same substance classes a rapid identification of inorganic and organometallic pollutants is of critical importance tetraoctyl tin exhibits an LC50 of 50000 mg/kg in comparison the LC50 of triethyl tin is 4 mg/kg Sn (II) is not toxic Hg, Cd, Tl, Ni ions etc., are highly toxic. 

The action of triethyl tin, triethyl lead, ethyl mercmy and other inhibitors on... 

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